Shi Shaoli, Li Guangyao, Zhu Xiaoli, Kong Lingming
Psychiatry Department, The 5th People's Hospital of Luoyang, Luoyang, Henan Province, 471027, People's Republic of China.
Treatment & Prevention Center, No. 904th Hospital, Changzhou, Jiangsu Province, 213003, People's Republic of China.
Neuropsychiatr Dis Treat. 2024 Nov 12;20:2115-2124. doi: 10.2147/NDT.S476992. eCollection 2024.
Adolescent group may be prone to a variety of behavioral disorders, one of which is nonsuicidal self-injury (NSSI), NSSI intervention is limited for its unknown mechanism, so this study aimed to explore the factors associated with and pathological mechanism underlying NSSI from the perspective of family dysfunction, alexithymia, circRNA_103636 in a sample of Chinese adolescents.
A total of 200 MDD adolescents with NSSI and 200 healthy controls were enrolled via a convenient sampling method in clinical settings. The Family APGAR Index (APGAR), Toronto Alexithymia Scale (TAS-20), and Adolescent Nonsuicidal Self-injury Assessment Questionnaire (ANSSIAQ) were used for mental assessment of the study group and control group participants. Real-time quantitative reverse transcription PCR (qRT-PCR) was utilized to detect circRNA_103636 expression in peripheral blood mononuclear cells (PBMCs).
There were significant between-group differences of 134 patients (67%) in the study group and 42 patients in the control group (21%) with moderate or severe family dysfunction (P<0.01). The APGAR score was lower, and the difficulty identifying feeling (DIF), difficulty describing feeling (DDF) and externally oriented thinking (EOT) scores of the TAS-20 and ΔCt value of circRNA_103636 were greater in the study group than in the control group. NSSI behavior and NSSI function were negatively correlated with the APGAR score and positively correlated with DIF, DDF, and the EOT of TAS-20 and the ΔCt value of circRNA_103636. Multiple regression analysis confirmed that EOT, circRNA_103636 expression, and APGAR were predictors of ANSSIAQ, which could explain 40.5% of the variance. Similarly, the alexithymia and circRNA_103636 expression mediated the correlation between family dysfunction and NSSI in the study group, and these mediating effects accounted for 27.25% and 23.33%, respectively, of the total effect. Taken together, family dysfunction, alexithymia, and circRNA_103636 expression have predictive effects on NSSI and alexithymia, circRNA_103636 expressions are mediators between family dysfunction and NSSI in Chinese adolescent.
Here, we established a new model for NSSI in which exposure to family dysfunction could induce pathological process by modulating personality traits and epigenetic regulators.
青少年群体可能容易出现多种行为障碍，其中之一是非自杀性自伤（NSSI），由于NSSI的机制尚不清楚，其干预措施有限，因此本研究旨在从家庭功能障碍、述情障碍、circRNA_103636的角度，在中国青少年样本中探索与NSSI相关的因素及其病理机制。
通过便利抽样法在临床环境中招募了200名患有NSSI的抑郁症青少年和200名健康对照者。使用家庭APGAR指数（APGAR）、多伦多述情障碍量表（TAS-20）和青少年非自杀性自伤评估问卷（ANSSIAQ）对研究组和对照组参与者进行心理评估。采用实时定量逆转录PCR（qRT-PCR）检测外周血单个核细胞（PBMCs）中circRNA_103636的表达。
研究组134例患者（67%）和对照组42例患者（21%）存在中度或重度家庭功能障碍，组间差异有统计学意义（P<0.01）。研究组的APGAR评分较低，TAS-20的难以识别情感（DIF）、难以描述情感（DDF）和外向性思维（EOT）得分以及circRNA_103636的ΔCt值均高于对照组。NSSI行为和NSSI功能与APGAR评分呈负相关，与TAS-20的DIF、DDF和EOT以及circRNA_103636的ΔCt值呈正相关。多元回归分析证实，EOT、circRNA_103636表达和APGAR是ANSSIAQ的预测因子，可解释40.5%的方差。同样，在研究组中，述情障碍和circRNA_103636表达介导了家庭功能障碍与NSSI之间的相关性，这些中介效应分别占总效应的27.25%和23.33%。综上所述，家庭功能障碍、述情障碍和circRNA_103636表达对NSSI具有预测作用，在中国青少年中，circRNA_103636表达是家庭功能障碍与NSSI之间的中介因子。
在此，我们建立了一种新的NSSI模型，其中家庭功能障碍的暴露可通过调节人格特质和表观遗传调节因子诱导病理过程。
