儿童高血压的诊断、流行病学及管理
Diagnosis, Epidemiology, and Management of Hypertension in Children.
作者信息
Rao Goutham
机构信息
Ambulatory Primary Care Innovations Group (APCIG) and Department of Family Medicine, NorthShore University HealthSystem, Evanston, Illinois; Pritzker School of Medicine, University of Chicago, Chicago, Illinois; and Department of Family Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio
出版信息
Pediatrics. 2016 Aug;138(2). doi: 10.1542/peds.2015-3616. Epub 2016 Jul 12.
National guidelines for the diagnosis and management of hypertension in children have been available for nearly 40 years. Unfortunately, knowledge and recognition of the problem by clinicians remain poor. Prevalence estimates are highly variable because of differing standards, populations, and blood pressure (BP) measurement techniques. Estimates in the United States range from 0.3% to 4.5%. Risk factors for primary hypertension include overweight and obesity, male sex, older age, high sodium intake, and African American or Latino ancestry. Data relating hypertension in childhood to later cardiovascular events is currently lacking. It is known that BP in childhood is highly predictive of BP in adulthood. Compelling data about target organ damage is available, including the association of hypertension with left ventricular hypertrophy, carotid-intima media thickness, and microalbuminuria. Guidelines from both the United States and Europe include detailed recommendations for diagnosis and management. Diagnostic standards are based on clinic readings, ambulatory BP monitoring is useful in confirming diagnosis of hypertension and identifying white-coat hypertension, masked hypertension, and secondary hypertension, as well as monitoring response to therapy. Research priorities include the need for reliable prevalence estimates based on diverse populations and data about the long-term impact of childhood hypertension on cardiovascular morbidity and mortality. Priorities to improve clinical practice include more education among clinicians about diagnosis and management, clinical decision support to aid in diagnosis, and routine use of ambulatory BP monitoring to aid in diagnosis and to monitor response to treatment.
儿童高血压诊断与管理的国家指南已经出台近40年了。不幸的是,临床医生对这一问题的认识和了解仍然不足。由于标准、人群和血压测量技术的不同,患病率估计差异很大。美国的估计范围为0.3%至4.5%。原发性高血压的危险因素包括超重和肥胖、男性、年龄较大、高钠摄入以及非裔美国人或拉丁裔血统。目前缺乏关于儿童期高血压与后期心血管事件之间关系的数据。已知儿童期血压对成年期血压具有高度预测性。关于靶器官损害的有力数据是可用的,包括高血压与左心室肥厚、颈动脉内膜中层厚度和微量白蛋白尿之间的关联。美国和欧洲的指南都包括了关于诊断和管理的详细建议。诊断标准基于诊所测量值,动态血压监测有助于确诊高血压,并识别白大衣高血压、隐匿性高血压和继发性高血压,以及监测治疗反应。研究重点包括需要基于不同人群得出可靠的患病率估计值,以及关于儿童高血压对心血管发病率和死亡率长期影响的数据。改善临床实践的重点包括对临床医生进行更多关于诊断和管理的教育、提供有助于诊断的临床决策支持,以及常规使用动态血压监测来辅助诊断和监测治疗反应。