Martyniak Adrian, Drożdż Dorota, Tomasik Przemysław J
Department of Clinical Biochemistry, Institute of Pediatrics, Jagiellonian University Medical College, 30-663 Krakow, Poland.
Department of Pediatric Nephrology and Hypertension, Institute of Pediatrics, Jagiellonian University Medical College, 30-663 Krakow, Poland.
Biomedicines. 2024 Mar 10;12(3):620. doi: 10.3390/biomedicines12030620.
Primary hypertension (PH) is the leading form of arterial hypertension (AH) in adolescents. Hypertension is most common in obese patients, where 20 to 40% of the population has elevated blood pressure. One of the most effective mechanisms for regulating blood pressure is the renin-angiotensin-aldosterone system (RAAS). The new approach to the RAAS talks about two opposing pathways between which a state of equilibrium develops. One of them is a classical pathway, which is responsible for increasing blood pressure and is represented mainly by the angiotensin II (Ang II) peptide and, to a lesser extent, by angiotensin IV (Ang IV). The alternative pathway is responsible for the decrease in blood pressure and is mainly represented by angiotensin 1-7 (Ang 1-7) and angiotensin 1-9 (Ang 1-9). Our research study aimed to assess changes in angiotensin II, angiotensin IV, angiotensin 1-7, and angiotensin 1-9 concentrations in the plasma of adolescents with hypertension, with hypertension and obesity, and obesity patients. The Ang IV concentration was lower in hypertension + obesity versus control and obesity versus control, respectively = 0.01 and = 0.028. The Ang 1-9 concentration was lower in the obesity group compared to the control group ( = 0.036). There were no differences in Ang II and Ang 1-7 peptide concentrations in the hypertension, hypertension and obesity, obesity, and control groups. However, differences were observed in the secondary peptides, Ang IV and Ang 1-9. In both cases, the differences were related to obesity.
原发性高血压（PH）是青少年动脉高血压（AH）的主要形式。高血压在肥胖患者中最为常见，其中20%至40%的人群血压升高。调节血压最有效的机制之一是肾素-血管紧张素-醛固酮系统（RAAS）。RAAS的新观点认为存在两条相互对立的途径，它们之间会形成一种平衡状态。其中一条是经典途径，负责升高血压，主要由血管紧张素II（Ang II）肽代表，血管紧张素IV（Ang IV）的作用较小。另一条途径负责降低血压，主要由血管紧张素1-7（Ang 1-7）和血管紧张素1-9（Ang 1-9）代表。我们的研究旨在评估高血压青少年、高血压合并肥胖青少年以及肥胖患者血浆中血管紧张素II、血管紧张素IV、血管紧张素1-7和血管紧张素1-9浓度的变化。与对照组相比，高血压合并肥胖组和肥胖组的Ang IV浓度较低，分别为P = 0.01和P = 0.028。肥胖组的Ang 1-9浓度低于对照组（P = 0.036）。高血压组、高血压合并肥胖组、肥胖组和对照组的Ang II和Ang 1-7肽浓度没有差异。然而，在二级肽Ang IV和Ang 1-9中观察到了差异。在这两种情况下，差异都与肥胖有关。
