Svec F, Richards R J, Porter J R
a Obesity Research Program, Departments of Medicine and Physiology , Louisiana State University Medical School , 1542 Tulane Ave, New Orleans , LA 70112 , USA.
Nutr Neurosci. 1998;1(2):93-101. doi: 10.1080/1028415X.1998.11747218.
Treatment with dehydroepiandrosterone (DHEA) leads to a decrease in the fat stores of a variety of rodent models of obesity. However, whether DHEA affects food intake and whether such changes are important at reducing obesity is not settled. Some state that food intake is not altered by DHEA and that the effect on weight gain is caused by induced inefficiencies in metabolism. Others report that DHEA leads to a prompt decrease in caloric consumption and that this change is important in causing weight loss. In this commentary the data supporting both sides of this controversy are reviewed. Analysis suggests that these radically different conclusions are caused by investigators using studies of different experimental design; shorter experiments emphasize DHEA's effects on food intake, while longer experiments tend to emphasize DHEA's metabolic effects. In addition the way the investigators normalize their food intake results for differences in animal size may influence their analyses. It is concluded that DHEA exerts both a metabolic effect and an effect on caloric intake and that both are involved in medicating changes in fat stores of obese animals.
用脱氢表雄酮（DHEA）进行治疗会导致多种肥胖啮齿动物模型的脂肪储备减少。然而，DHEA是否会影响食物摄入量以及这种变化在减轻肥胖方面是否重要尚无定论。一些人指出，DHEA不会改变食物摄入量，对体重增加的影响是由诱导的代谢效率低下引起的。另一些人则报告说，DHEA会导致热量消耗迅速减少，这种变化对体重减轻很重要。在这篇评论中，回顾了支持这场争议双方的数据。分析表明，这些截然不同的结论是由采用不同实验设计的研究人员造成的；较短的实验强调DHEA对食物摄入量的影响，而较长的实验往往强调DHEA的代谢影响。此外，研究人员针对动物体型差异对食物摄入量结果进行标准化的方式可能会影响他们的分析。得出的结论是，DHEA既具有代谢作用，又对热量摄入有影响，且两者都参与调节肥胖动物脂肪储备的变化。
