Aldrich M S, Rogers A E
Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109/0316.
Sleep. 1989 Jun;12(3):254-6. doi: 10.1093/sleep/12.3.254.
A middle-aged woman with narcolepsy developed a pronounced exacerbation of cataplexy within 3 days of beginning treatment for hypertension with prazosin, an alpha 1-adrenoceptor antagonist. At times, episodes of cataplexy were virtually continuous (status cataplecticus), and there was only partial amelioration with tricyclic antidepressants. Cataplexy improved when prazosin was discontinued. These findings are similar to the reported effects of prazosin on cataplexy in narcoleptic dogs; they support a role for altered alpha 1-adrenoceptor function in narcolepsy.
一名患有发作性睡病的中年女性在开始使用α1肾上腺素能受体拮抗剂哌唑嗪治疗高血压后的3天内，猝倒症状明显加重。有时，猝倒发作几乎持续不断（猝倒状态），三环类抗抑郁药只能部分缓解症状。停用哌唑嗪后，猝倒症状有所改善。这些发现与报道的哌唑嗪对发作性睡病犬猝倒的影响相似；它们支持α1肾上腺素能受体功能改变在发作性睡病中的作用。
