匹配的异基因干细胞移植后严重再生障碍性贫血发生白血病转化，在完全缓解1期再次进行移植。
Leukemic Transformation of Severe Aplastic Anemia Following Matched Allogenic Stem Cell Transplantation, Transplanted Again in CR 1.
作者信息
Manivannan Prabhu, Purohit Abhishek, Somasundaram Venkatesan, Ahuja Ankur, Aggarwal Mukul, Kumar Rajiv, Singh Pawan Kumar, Pati Hara Prasad, Mishra Pravas, Seth Tulika, Mahapatra Manoranjan
机构信息
Department of Hematology, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, 110068 India.
出版信息
Indian J Hematol Blood Transfus. 2016 Jun;32(Suppl 1):223-7. doi: 10.1007/s12288-014-0484-z. Epub 2014 Dec 11.
Aplastic anemia (AA) is a life-threatening bone marrow failure disorder, if untreated, is associated with very high mortality. Allogenic bone marrow transplantation (BMT) is the standard of care for severe aplastic anemia (SAA) patients those who are younger than 40 years of age. The development of secondary malignancies in post-BMT setting for AA is a rare, however, well documented phenomenon. Among the secondary malignancies, development of acute myeloid leukemia is even rarer entity. Here we report a case of acute myeloid leukemia following human leucocyte antigen (HLA) matched sibling peripheral blood stem cell transplant (PBSCT) in a case of SAA. The patient achieved complete remission (CR) following chemotherapy and in CR1, a second HLA matched PBSCT from a different donor was offered. The patient is presently in remission at day +180 post-PBSCT.
再生障碍性贫血（AA）是一种危及生命的骨髓衰竭性疾病，若不治疗，死亡率极高。异基因骨髓移植（BMT）是40岁以下重型再生障碍性贫血（SAA）患者的标准治疗方法。AA患者BMT后发生继发性恶性肿瘤是一种罕见但有充分文献记载的现象。在继发性恶性肿瘤中，急性髓系白血病的发生更为罕见。在此，我们报告1例SAA患者在接受人类白细胞抗原（HLA）匹配的同胞外周血干细胞移植（PBSCT）后发生急性髓系白血病的病例。该患者化疗后达到完全缓解（CR），在CR1期，提供了来自另一位供者的第二次HLA匹配的PBSCT。该患者目前在PBSCT后第180天处于缓解状态。
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