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相似文献

1
Lithium to the Rescue.锂来救援。
Cerebrum. 2016 Feb 1;2016. eCollection 2016 Jan-Feb.
2
[The role of lithium in neurodegenerative diseases: new registries for old actors].
Neurologia. 2009 Apr;24(3):143-6.
3
Using antipsychotic agents in older patients.在老年患者中使用抗精神病药物。
J Clin Psychiatry. 2004;65 Suppl 2:5-99; discussion 100-102; quiz 103-4.
4
[Neuroprotective actions of lithium].[锂的神经保护作用]
Seishin Shinkeigaku Zasshi. 2003;105(1):81-6.
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Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness.锂在体内上调中枢神经系统中的细胞保护蛋白Bcl-2:对躁郁症的神经营养和神经保护作用
J Clin Psychiatry. 2000;61 Suppl 9:82-96.
6
Maintenance therapies in bipolar disorder: focus on randomized controlled trials.双相情感障碍的维持治疗:聚焦于随机对照试验。
Aust N Z J Psychiatry. 2005 Aug;39(8):652-61. doi: 10.1080/j.1440-1614.2005.01649.x.
7
Rationale for using lithium in combination with other mood stabilizers in the management of bipolar disorder.在双相情感障碍治疗中联合使用锂盐与其他心境稳定剂的理论依据。
J Clin Psychiatry. 2003;64 Suppl 5:18-24.
8
What is a "mood stabilizer"? An evidence-based response.什么是“心境稳定剂”?基于证据的回答。
Am J Psychiatry. 2004 Jan;161(1):3-18. doi: 10.1176/appi.ajp.161.1.3.
9
The Expert Consensus Guideline Series: Medication Treatment of Bipolar Disorder 2000.《专家共识指南系列:双相情感障碍的药物治疗(2000年版)》
Postgrad Med. 2000 Apr;Spec No:1-104.
10
A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients.锂盐治疗对治疗反应性双相情感障碍患者前额叶及膝下前额叶灰质体积影响的纵向研究。
J Clin Psychiatry. 2009 Apr 21;70(5):699-705. doi: 10.4088/JCP.07m03745.

引用本文的文献

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The link between endocrine parameters, serum lithium concentrations, and cognitive functions among individuals with affective disorders at risk of suicidal behavior. A study protocol.有自杀行为风险的情感障碍患者的内分泌参数、血清锂浓度与认知功能之间的联系。一项研究方案。
PLoS One. 2024 Dec 16;19(12):e0311347. doi: 10.1371/journal.pone.0311347. eCollection 2024.
2
Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder.在淋巴母细胞中进行转录组学和 miRNA 组学数据的整合,突出了免疫相关功能在双相情感障碍锂治疗反应中的关键作用。
BMC Psychiatry. 2022 Oct 27;22(1):665. doi: 10.1186/s12888-022-04286-3.
3
Hyperosmolar Ionic Solutions Modulate Inflammatory Phenotype and sGAG Loss in a Cartilage Explant Model.高渗离子溶液调节软骨外植体模型中的炎症表型和 sGAG 丢失。
Cartilage. 2021 Dec;13(2_suppl):713S-721S. doi: 10.1177/1947603520961167. Epub 2020 Sep 25.
4
Putative Mechanisms of Action and Clinical Use of Lithium in Children and Adolescents: A Critical Review.锂在儿童和青少年中的作用机制及临床应用:批判性综述。
Curr Neuropharmacol. 2019;17(4):318-341. doi: 10.2174/1570159X16666171219142120.

本文引用的文献

1
Lithium as a Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis.锂作为阿尔茨海默病的一种治疗方法:系统评价与荟萃分析
J Alzheimers Dis. 2015;48(2):403-10. doi: 10.3233/JAD-150437.
2
Invited commentary on … Lithium treatment and risk for dementia in adults with bipolar disorder.邀请评论…锂治疗和双相情感障碍成人痴呆风险。
Br J Psychiatry. 2015 Jul;207(1):52-4. doi: 10.1192/bjp.bp.114.161729.
3
Lithium treatment and risk for dementia in adults with bipolar disorder: population-based cohort study.锂治疗与双相情感障碍成人痴呆风险:基于人群的队列研究。
Br J Psychiatry. 2015 Jul;207(1):46-51. doi: 10.1192/bjp.bp.114.154047. Epub 2015 Jan 22.
4
Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits.炎症与锂:揭示导致与自杀相关特征的机制的线索。
Transl Psychiatry. 2014 Dec 16;4(12):e488. doi: 10.1038/tp.2014.129.
5
Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases.糖原合酶激酶-3(GSK3):调控、作用及相关疾病
Pharmacol Ther. 2015 Apr;148:114-31. doi: 10.1016/j.pharmthera.2014.11.016. Epub 2014 Nov 27.
6
Lithium in drinking water and suicide prevention: a review of the evidence.饮用水中的锂与自杀预防:证据综述
Int Clin Psychopharmacol. 2015 Jan;30(1):1-5. doi: 10.1097/YIC.0000000000000048.
7
A new avenue for lithium: intervention in traumatic brain injury.锂的新途径:干预创伤性脑损伤。
ACS Chem Neurosci. 2014 Jun 18;5(6):422-33. doi: 10.1021/cn500040g. Epub 2014 Apr 11.
8
Lessons learnt from glycogen synthase kinase 3 inhibitors development for Alzheimer's disease.从阿尔茨海默病糖原合酶激酶 3 抑制剂的研发中吸取的经验教训。
Curr Top Med Chem. 2013;13(15):1808-19. doi: 10.2174/15680266113139990138.
9
Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.糖原合酶激酶-3 对 Th1 细胞和实验性自身免疫性脑脊髓炎的调节作用。
J Immunol. 2013 May 15;190(10):5000-11. doi: 10.4049/jimmunol.1203057. Epub 2013 Apr 19.
10
Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease.糖原合酶激酶-3 抑制剂作为治疗帕金森病的有效治疗药物。
ACS Chem Neurosci. 2013 Feb 20;4(2):350-60. doi: 10.1021/cn300182g. Epub 2012 Dec 5.

锂来救援。

Lithium to the Rescue.

作者信息

Jope Richard S, Nemeroff Charles B

出版信息

Cerebrum. 2016 Feb 1;2016. eCollection 2016 Jan-Feb.

PMID:27408673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4938258/
Abstract

Lithium, an element that Mother Nature has put in some drinking water sources, has been used for its curative powers for centuries. Today, it's given in capsule form as a mood stabilizer for bipolar disorder and depression. New research, however, reveals its role as a neuroprotector, and suggests that a better understanding of the role enzymes modulated by lithium play could lead to new treatments for Alzheimer's disease, Parkinson's disease, multiple sclerosis, and other neurodegenerative disorders.

摘要

锂,一种大自然存在于某些饮用水源中的元素,几个世纪以来一直因其治疗功效而被使用。如今,它以胶囊形式作为双相情感障碍和抑郁症的情绪稳定剂。然而,新的研究揭示了它作为神经保护剂的作用,并表明更好地理解锂调节的酶所起的作用可能会带来针对阿尔茨海默病、帕金森病、多发性硬化症和其他神经退行性疾病的新疗法。