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SkfB Abstracts a Hydrogen Atom from Cα on SkfA To Initiate Thioether Cross-Link Formation.SkfB从SkfA上的Cα提取一个氢原子以启动硫醚交联形成。
Biochemistry. 2016 Aug 2;55(30):4131-4. doi: 10.1021/acs.biochem.6b00598. Epub 2016 Jul 21.
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A Radical Clock Probe Uncouples H Atom Abstraction from Thioether Cross-Link Formation by the Radical S-Adenosyl-l-methionine Enzyme SkfB.一种自由基时钟探针将硫醚交联形成过程中的氢原子提取与自由基S-腺苷-L-甲硫氨酸酶SkfB解偶联。
Biochemistry. 2018 Aug 14;57(32):4816-4823. doi: 10.1021/acs.biochem.8b00537. Epub 2018 Jul 24.
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Two [4Fe-4S] clusters containing radical SAM enzyme SkfB catalyze thioether bond formation during the maturation of the sporulation killing factor.两个[4Fe-4S]簇包含了自由基 SAM 酶 SkfB，在芽孢致死因子成熟过程中催化硫醚键的形成。
J Am Chem Soc. 2013 Jan 23;135(3):959-62. doi: 10.1021/ja310542g. Epub 2013 Jan 9.
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Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides.生物信息学映射激进 S-腺苷甲硫氨酸依赖性核糖体合成和翻译后修饰肽鉴定新的 Cα、Cβ 和 Cγ 连接的含硫醚肽。
J Am Chem Soc. 2019 May 22;141(20):8228-8238. doi: 10.1021/jacs.9b01519. Epub 2019 May 13.
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Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-L-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link.参与肽硫醚交联形成的自由基S-腺苷-L-甲硫氨酸酶的生化与光谱表征
Biochemistry. 2016 Apr 12;55(14):2122-34. doi: 10.1021/acs.biochem.6b00145. Epub 2016 Apr 1.
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Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides.硫醚键在 sactipeptides 生物合成中的结构研究
J Am Chem Soc. 2017 Aug 30;139(34):11734-11744. doi: 10.1021/jacs.7b01283. Epub 2017 Aug 21.
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The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A.激进的 SAM 酶 AlbA 催化枯草菌素 A 中的硫醚键形成。
Nat Chem Biol. 2012 Feb 26;8(4):350-7. doi: 10.1038/nchembio.798.
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Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase.结构和光谱分析的孢子形成杀伤因子生物合成酶 SkfB，一种细菌 AdoMet 自由基 sactisynthase。
J Biol Chem. 2018 Nov 9;293(45):17349-17361. doi: 10.1074/jbc.RA118.005369. Epub 2018 Sep 14.
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Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes.人肠道微生物组合成 sactipeptide Ruminococcin C：通过自由基 SAM 酶形成硫醚键的机制见解。
J Biol Chem. 2020 Dec 4;295(49):16665-16677. doi: 10.1074/jbc.RA120.015371. Epub 2020 Sep 24.
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The biosynthesis of thiol- and thioether-containing cofactors and secondary metabolites catalyzed by radical S-adenosylmethionine enzymes.由自由基S-腺苷甲硫氨酸酶催化的含硫醇和硫醚辅因子及次生代谢产物的生物合成。
J Biol Chem. 2015 Feb 13;290(7):3972-9. doi: 10.1074/jbc.R114.599308. Epub 2014 Dec 4.
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Catalytic Markovnikov Hydrothiolation of Dehydroamino Acids: Unified Total Synthesis of Enteropeptin Sactipeptides.脱氢氨基酸的催化马氏氢硫基化反应：肠肽类硫肽的统一全合成
J Am Chem Soc. 2025 Aug 27;147(34):30661-30673. doi: 10.1021/jacs.5c03669. Epub 2025 Aug 14.
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Synergistic action of two radical SAM enzymes in the biosynthesis of thuricin CD, a two-component sactibiotic.两种自由基S-腺苷甲硫氨酸酶在双组分硫肽抗生素thuricin CD生物合成中的协同作用。
Chem Sci. 2025 May 8. doi: 10.1039/d5sc01546d.
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Total Synthesis and Stereochemical Assignment of Enteropeptin A.肠促胰酶肽 A 的全合成及立体化学构型确定。
J Am Chem Soc. 2024 Jul 3;146(26):17629-17635. doi: 10.1021/jacs.4c06126. Epub 2024 Jun 23.
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Hydrogen-Deuterium Exchange Mass Spectrometry Identifies Local and Long-Distance Interactions within the Multicomponent Radical SAM Enzyme, PqqE.氢-氘交换质谱法鉴定多组分自由基S-腺苷甲硫氨酸酶PqqE内的局部和远距离相互作用。
ACS Cent Sci. 2024 Jan 17;10(2):251-263. doi: 10.1021/acscentsci.3c01023. eCollection 2024 Feb 28.
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Direct Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical -Adenosyl-l-methionine Peptide Epimerization.直接检测由 OspD 形成的 α-碳自由基中间体：对自由基 -S-腺苷甲硫氨酸肽差向异构化的机理见解。
J Am Chem Soc. 2024 Feb 28;146(8):5550-5559. doi: 10.1021/jacs.3c13829. Epub 2024 Feb 16.
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Peptide Selenocysteine Substitutions Reveal Direct Substrate-Enzyme Interactions at Auxiliary Clusters in Radical -Adenosyl-l-methionine Maturases.肽硒代半胱氨酸取代揭示了在自由基 -腺苷基-l-甲硫氨酸甲基转移酶辅助簇中的直接底物-酶相互作用。
J Am Chem Soc. 2023 May 10;145(18):10167-10177. doi: 10.1021/jacs.3c00831. Epub 2023 Apr 27.
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How a Subfamily of Radical S-Adenosylmethionine Enzymes Became a Mainstay of Ribosomally Synthesized and Post-translationally Modified Peptide Discovery.自由基S-腺苷甲硫氨酸酶的一个亚家族如何成为核糖体合成及翻译后修饰肽发现的中流砥柱。
ACS Bio Med Chem Au. 2021 Dec 2;2(1):53-59. doi: 10.1021/acsbiomedchemau.1c00045. eCollection 2022 Feb 16.
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A scalable platform to discover antimicrobials of ribosomal origin.一种可扩展的平台，用于发现核糖体来源的抗菌药物。
Nat Commun. 2022 Oct 17;13(1):6135. doi: 10.1038/s41467-022-33890-w.
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Sactipeptide Engineering by Probing the Substrate Tolerance of a Thioether-Bond-Forming Sactisynthase.通过探测硫醚键形成酶的底物耐受性来进行 Sactipeptide 工程改造。
Angew Chem Int Ed Engl. 2022 Nov 7;61(45):e202210883. doi: 10.1002/anie.202210883. Epub 2022 Oct 12.
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ThnL, a B12-dependent radical -adenosylmethionine enzyme, catalyzes thioether bond formation in carbapenem biosynthesis.ThnL，一种依赖 B12 的自由基 - 腺苷甲硫氨酸酶，催化碳青霉烯生物合成中的硫醚键形成。
Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2206494119. doi: 10.1073/pnas.2206494119. Epub 2022 Aug 15.
本文引用的文献
1
Thioether bond formation by SPASM domain radical SAM enzymes: Cα H-atom abstraction in subtilosin A biosynthesis.SPASM结构域自由基S-腺苷甲硫氨酸酶催化硫醚键形成：枯草菌素A生物合成中的Cα氢原子提取
Chem Commun (Camb). 2016 May 7;52(37):6249-6252. doi: 10.1039/c6cc01317a. Epub 2016 Apr 18.
2
Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-L-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link.参与肽硫醚交联形成的自由基S-腺苷-L-甲硫氨酸酶的生化与光谱表征
Biochemistry. 2016 Apr 12;55(14):2122-34. doi: 10.1021/acs.biochem.6b00145. Epub 2016 Apr 1.
3
Mechanistic Studies of the Radical S-Adenosyl-L-methionine Enzyme 4-Demethylwyosine Synthase Reveal the Site of Hydrogen Atom Abstraction.自由基S-腺苷-L-甲硫氨酸酶4-去甲基怀俄苷合成酶的机制研究揭示了氢原子提取位点。
Biochemistry. 2015 Jun 16;54(23):3569-72. doi: 10.1021/acs.biochem.5b00476. Epub 2015 Jun 8.
4
The PqqD homologous domain of the radical SAM enzyme ThnB is required for thioether bond formation during thurincin H maturation.在thurincin H成熟过程中，自由基S-腺苷甲硫氨酸酶ThnB的PqqD同源结构域是硫醚键形成所必需的。
FEBS Lett. 2015 Jul 8;589(15):1802-6. doi: 10.1016/j.febslet.2015.05.032. Epub 2015 May 27.
5
Chemical and Biological Reduction of the Radical SAM Enzyme 7-Carboxy-7-deazaguanine [corrected] Synthase.自由基SAM酶7-羧基-7-脱氮鸟嘌呤[校正后]合酶的化学和生物还原
Biochemistry. 2015 May 12;54(18):2903-10. doi: 10.1021/acs.biochem.5b00210. Epub 2015 May 1.
6
Two [4Fe-4S] clusters containing radical SAM enzyme SkfB catalyze thioether bond formation during the maturation of the sporulation killing factor.两个[4Fe-4S]簇包含了自由基 SAM 酶 SkfB，在芽孢致死因子成熟过程中催化硫醚键的形成。
J Am Chem Soc. 2013 Jan 23;135(3):959-62. doi: 10.1021/ja310542g. Epub 2013 Jan 9.
7
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.核糖体合成和翻译后修饰的肽类天然产物：概述及通用命名建议。
Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f.
8
The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A.激进的 SAM 酶 AlbA 催化枯草菌素 A 中的硫醚键形成。
Nat Chem Biol. 2012 Feb 26;8(4):350-7. doi: 10.1038/nchembio.798.
9
Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis.种内代谢交换的成像质谱分析揭示了枯草芽孢杆菌的自噬因子。
Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16286-90. doi: 10.1073/pnas.1008368107. Epub 2010 Aug 30.
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Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile.梭菌噬菌体素 CD，一种经翻译后修饰的窄谱抗菌肽，对艰难梭菌具有活性。
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9352-7. doi: 10.1073/pnas.0913554107. Epub 2010 Apr 30.
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