Qu Xiaozhong, Yang Zhenzhong
State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Chem Asian J. 2016 Oct 6;11(19):2633-2641. doi: 10.1002/asia.201600452. Epub 2016 Aug 18.
The benzoic imine is a dynamic covalent bond, which is stable around neutral pH value (ca. 7.4), but starts to hydrolyze at the extracellular pH value of solid tumors (ca. 6.5) and rapidly disintegrates at endosome and lysosome pH values (ca. 4.5-6.5). This characteristic is promising for the construction of physiological-pH-responsive materials, such as polymeric micelles, nanoparticles, and hydrogels for pharmaceutical and tissue-engineering applications. This Focus Review summarizes recent progress in the design and synthesis of pH-sensitive materials that contain the benzoic imine bond with biomedical objectives.
苯甲亚胺是一种动态共价键，在中性pH值（约7.4）附近稳定，但在实体瘤的细胞外pH值（约6.5）时开始水解，并在内体和溶酶体的pH值（约4.5 - 6.5）下迅速分解。这一特性对于构建生理pH响应性材料很有前景，例如用于药物和组织工程应用的聚合物胶束、纳米颗粒和水凝胶。本重点综述总结了含苯甲亚胺键的pH敏感材料在设计与合成方面的最新进展，这些进展以生物医学为目标。
