Lee Sun-Min, Kim-Ha Jeongsil, Choi Won-Young, Lee Jungwoo, Kim Dawon, Lee Jinyoung, Choi Eunji, Kim Young-Joon
Department of Biochemistry, College of Life Science & Technology, Yonsei University, Seoul, Korea.
Department of Integrative Bioscience & Biotechnology, College of Life Sciences, Sejong University, Seoul, Korea.
Epigenomics. 2016 Jul;8(7):993-1005. doi: 10.2217/epi-2016-0027. Epub 2016 Jul 14.
Genetic and epigenetic alterations play prominent roles in hepatocarcinogenesis and their appearance varies depending on etiological factors, race and tumor progression. Intriguingly, distinct patterns of these genetic and epigenetic mutations are coupled not only to affect each other, but to trigger different types of tumorigenesis. The patterns and frequencies of somatic variations vary depending on the nature of the surrounding chromatin. On the other hand, epigenetic alterations often induce genomic instability prone to mutation. Therefore, genetic mutations and epigenetic alterations in hepatocellular carcinoma appear to be inseparable factors that accelerate tumorigenesis synergistically. We have summarized recent findings on genetic and epigenetic modifications, their influences on each other's alterations and putative roles in liver tumorigenesis.
遗传和表观遗传改变在肝癌发生过程中起着重要作用，其表现因病因、种族和肿瘤进展而异。有趣的是，这些遗传和表观遗传突变的不同模式不仅相互影响，还会引发不同类型的肿瘤发生。体细胞变异的模式和频率因周围染色质的性质而异。另一方面，表观遗传改变常常诱导易于发生突变的基因组不稳定。因此，肝细胞癌中的基因突变和表观遗传改变似乎是协同加速肿瘤发生的不可分割的因素。我们总结了关于遗传和表观遗传修饰的最新发现、它们对彼此改变的影响以及在肝脏肿瘤发生中的假定作用。
