表观遗传异常在人类肝细胞癌发生发展中的作用。
Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma.
机构信息
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States.
出版信息
Cancer Lett. 2014 Jan 28;342(2):223-30. doi: 10.1016/j.canlet.2012.01.038. Epub 2012 Feb 2.
Abstract
Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in humans. The molecular mechanisms leading to the development of HCC are extremely complicated and consist of prominent genetic, genomic, and epigenetic alterations. This review summarizes the current knowledge of the role of epigenetic aberrations, including changes in DNA methylation, histone modifications, and expression of microRNAs in the pathogenesis of HCC. It also emphasizes that identification of the underlying epigenetic alterations that drive cell transformation and promote development and progression of HCC is crucially important for understanding mechanisms of hepatocarcinogenesis, its detection, therapeutic intervention, and prevention.
摘要
肝细胞癌（HCC）是人类最致命和最常见的癌症之一。导致 HCC 发生的分子机制极其复杂，包括显著的遗传、基因组和表观遗传改变。本文综述了表观遗传异常在 HCC 发病机制中的作用，包括 DNA 甲基化、组蛋白修饰和 microRNAs 表达的改变。本文还强调，鉴定驱动细胞转化并促进 HCC 发生和发展的潜在表观遗传改变，对于理解肝癌发生机制、早期检测、治疗干预和预防至关重要。
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