Nanobioelectronics & Biosensors Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, Barcelona 08193, Spain.
Lab Chip. 2016 Aug 16;16(17):3150-76. doi: 10.1039/c6lc00737f.
This review shows the recent advances and state of the art in paper-based analytical devices (PADs) through the analysis of their integration with microfluidics and LOC micro- and nanotechnologies, electrochemical/optical detection and electronic devices as the convergence of various knowledge areas. The important role of the paper design/architecture in the improvement of the performance of sensor devices is discussed. The discussion is fundamentally based on μPADs as the new generation of paper-based (bio)sensors. Data about the scientific publication ranking of PADs, illustrating their increase as an experimental research topic in the past years, are supplied. In addition, an analysis of the simultaneous evolution of PADs in academic lab research and industrial commercialization highlighting the parallelism of the technological transfer from academia to industry is displayed. A general overview of the market behaviour, the leading industries in the sector and their commercialized devices is given. Finally, personal opinions of the authors about future perspectives and tendencies in the design and fabrication technology of PADs are disclosed.
本综述通过分析纸基分析器件 (PADs) 与微流控和 LOC 微纳技术、电化学/光学检测和电子设备的集成，展示了它们在该领域的最新进展和最新技术状态，这些技术领域的融合汇聚了各种知识领域。文中还讨论了纸张设计/结构在提高传感器设备性能方面的重要作用。讨论的基础是 μPADs，因为它是新一代基于纸张的（生物）传感器。文中还提供了有关 PADs 科学出版物排名的数据，这些数据表明 PADs 作为一个实验研究课题在过去几年中的增长情况。此外，还分析了 PADs 在学术实验室研究和工业商业化中的同时演变，突出了技术从学术界到工业界的转移具有平行性。本文还概述了市场行为、该领域的领先行业及其商业化设备。最后，作者还对 PADs 的设计和制造技术的未来展望和趋势提出了个人看法。
