Zeraatkar Dena, Nahari Ahmed, Wang Pei-Wen, Kearsley Emily, Falzone Nicole, Xu Michael, Banfield Laura, Thabane Lehana, Samaan M Constantine
Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.
Division of Pediatric Endocrinology, McMaster Children's Hospital, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.
Syst Rev. 2016 Jul 13;5(1):111. doi: 10.1186/s13643-016-0288-3.
The prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents is increasing. This has spurred the development and publication of clinical practice guidelines (CPGs) for the management of paediatric T2DM. Given the long-term complications of T2DM, optimal management is important to prevent or delay these complications. However, the quality of published CPGs has not yet been empirically evaluated. Our objective is to systematically appraise all published CPGs for the management of T2DM in children and adolescents.
We will identify all published CPGs that address T2DM in children and adolescents through MEDLINE, Embase, CINAHL, Trip, and the National Guideline Clearinghouse and will screen diabetes and paediatric societies and associations' websites. Search records will be screened in duplicate for inclusion. Grey literature will be covered by systematically searching publications of all relevant diabetes societies and associations and other health organizations for CPGs that meet our inclusion criteria. CPGs deemed eligible for inclusion will be retrieved. Quality assessment will be conducted using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool by a team of four appraisers. Scaled scores of the AGREE II will be used to gauge the overall quality of CPGs.
The results of this review will be disseminated through presentations at local, national, and international conferences and publication in a peer-reviewed journal. The results of this review can help improve the reporting of future guidelines, inform decisions of policy-makers to endorse CPGs, and affect the choice of guideline use in clinical practice.
PROSPERO CRD42016034187.
儿童和青少年2型糖尿病（T2DM）的患病率正在上升。这促使了针对儿童T2DM管理的临床实践指南（CPG）的制定和发布。鉴于T2DM的长期并发症，最佳管理对于预防或延缓这些并发症很重要。然而，已发表的CPG的质量尚未得到实证评估。我们的目标是系统评价所有已发表的关于儿童和青少年T2DM管理的CPG。
我们将通过MEDLINE、Embase、CINAHL、Trip和国家指南交换中心识别所有已发表的涉及儿童和青少年T2DM的CPG，并将筛查糖尿病和儿科协会及社团的网站。检索记录将进行双人筛查以确定是否纳入。灰色文献将通过系统搜索所有相关糖尿病协会及社团和其他卫生组织的出版物来获取符合我们纳入标准的CPG。被认为符合纳入条件的CPG将被检索。质量评估将由一个由四名评估者组成的团队使用《研究与评价指南评估II》（AGREE II）工具进行。AGREE II的量表分数将用于衡量CPG的整体质量。
本综述的结果将通过在地方、国家和国际会议上的报告以及在同行评审期刊上发表来传播。本综述的结果有助于改进未来指南的报告，为政策制定者认可CPG的决策提供信息，并影响临床实践中指南使用的选择。
PROSPERO CRD42016034187。
