直肠癌的新辅助治疗：我们目前处于什么阶段？ - Suppr

Neoadjuvant treatment of rectal cancer: where are we now?

作者信息

Kalyan Aparna, Rozelle Shaina, Benson Al

机构信息

Developmental Therapeutics Program of Division of Hematology & Oncology, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL USA Division of Hematology & Oncology, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL USA

Division of Hematology & Oncology, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL USA.

出版信息

Gastroenterol Rep (Oxf). 2016 Aug;4(3):206-9. doi: 10.1093/gastro/gow017. Epub 2016 Jul 12.

DOI:10.1093/gastro/gow017

PMID:27412436

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4976683/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4230/4976683/11e143312444/gow017f1p.jpg

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Neoadjuvant treatment of rectal cancer: where are we now?直肠癌的新辅助治疗：我们目前处于什么阶段？

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Transanal endoscopic microsurgery for residual rectal cancer (ypT0-2) following neoadjuvant chemoradiation therapy: another word of caution.新辅助放化疗后残留直肠癌（ypT0-2）经肛门内镜微创手术：另需谨慎。

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Accuracy of endoscopic ultrasound for restaging rectal cancer following neoadjuvant chemoradiation therapy.新辅助放化疗后内镜超声对直肠癌再分期的准确性

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Gene expression profiles of epidermal growth factor receptor, vascular endothelial growth factor and hypoxia-inducible factor-1 with special reference to local responsiveness to neoadjuvant chemoradiotherapy and disease recurrence after rectal cancer surgery.表皮生长因子受体、血管内皮生长因子和缺氧诱导因子-1 的基因表达谱，特别是与直肠癌手术后新辅助放化疗的局部反应性和疾病复发的关系。

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The role of tissue diagnosis prior to neoadjuvant chemoradiotherapy for locally advanced rectal cancer.组织诊断在局部晚期直肠癌新辅助放化疗前的作用。

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Predictive Significance of Mucinous Histology on Pathologic Complete Response Rate Following Capecitabine-Based Neoadjuvant Chemoradiation in Rectal Cancer: a Comparative Study.黏液组织学对直肠癌中基于卡培他滨的新辅助放化疗后病理完全缓解率的预测意义：一项对比研究

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Statin therapy is associated with improved pathologic response to neoadjuvant chemoradiation in rectal cancer.他汀类药物治疗与直肠癌新辅助放化疗的病理反应改善相关。

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本文引用的文献

Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis.放化疗后观察等待与手术切除治疗直肠癌患者的对比（OnCoRe 项目）：倾向评分匹配队列分析。

Lancet Oncol. 2016 Feb;17(2):174-183. doi: 10.1016/S1470-2045(15)00467-2. Epub 2015 Dec 17.

Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial.使用新辅助放化疗和局部切除对临床T2N0期低位直肠癌进行器官保留（ACOSOG Z6041）：一项开放标签、单臂、多机构的2期试验结果

Lancet Oncol. 2015 Nov;16(15):1537-1546. doi: 10.1016/S1470-2045(15)00215-6. Epub 2015 Oct 22.

Neoadjuvant chemoradiation therapy and pathological complete response in rectal cancer.新辅助放化疗与直肠癌的病理完全缓解。

Gastroenterol Rep (Oxf). 2015 Nov;3(4):277-88. doi: 10.1093/gastro/gov039. Epub 2015 Aug 19.

Neoadjuvant therapy before surgical treatment.手术治疗前的新辅助治疗。

EJC Suppl. 2013 Sep;11(2):45-59. doi: 10.1016/j.ejcsup.2013.07.032.

Cancer statistics, 2015.癌症统计数据，2015 年。

CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29. doi: 10.3322/caac.21254. Epub 2015 Jan 5.

Preoperative chemotherapy in patients with intermediate-risk rectal adenocarcinoma selected by high-resolution magnetic resonance imaging: the GEMCAD 0801 Phase II Multicenter Trial.通过高分辨率磁共振成像筛选的中危直肠腺癌患者的术前化疗：GEMCAD 0801 II期多中心试验

Oncologist. 2014 Oct;19(10):1042-3. doi: 10.1634/theoncologist.2014-0233. Epub 2014 Sep 10.

Neoadjuvant chemotherapy without routine use of radiation therapy for patients with locally advanced rectal cancer: a pilot trial.局部进展期直肠癌患者新辅助化疗不常规应用放疗：一项初步试验。

J Clin Oncol. 2014 Feb 20;32(6):513-8. doi: 10.1200/JCO.2013.51.7904. Epub 2014 Jan 13.

Evolving role of neoadjuvant therapy in rectal cancer.新辅助治疗在直肠癌中的作用演变。

Curr Treat Options Oncol. 2013 Sep;14(3):350-64. doi: 10.1007/s11864-013-0242-8.

Postoperative adjuvant chemotherapy use in patients with stage II/III rectal cancer treated with neoadjuvant therapy: a national comprehensive cancer network analysis.接受新辅助治疗的 II/III 期直肠癌患者的术后辅助化疗应用：美国国家综合癌症网络分析。

J Clin Oncol. 2013 Jan 1;31(1):30-8. doi: 10.1200/JCO.2011.40.3188. Epub 2012 Nov 19.

Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years.局部进展期直肠癌术前与术后放化疗的比较：中位随访 11 年后德国 CAO/ARO/AIO-94 随机 III 期临床试验结果。

J Clin Oncol. 2012 Jun 1;30(16):1926-33. doi: 10.1200/JCO.2011.40.1836. Epub 2012 Apr 23.

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Neoadjuvant treatment of rectal cancer: where are we now?

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