Graham Sheila V
MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, and College of Medical Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Glasgow, Scotland
J Virol. 2016 Sep 12;90(19):8384-8. doi: 10.1128/JVI.00502-16. Print 2016 Oct 1.
The human papillomavirus (HPV) life cycle is tightly linked to differentiation of the infected epithelium. This means that viral proteins must exert control over epithelial gene expression in order to optimize viral production. The HPV E2 protein controls replication, transcription, and viral genome partitioning during the viral infectious life cycle. It consists of a nucleic acid-binding domain and a protein-protein interaction domain separated by a flexible serine and arginine-rich hinge region. Over the last few years, mounting evidence has uncovered an important new role for E2 in viral and cellular RNA processing. This Gem discusses the role of E2 in controlling the epithelial cellular environment and how E2 might act to coordinate late events in the viral replication cycle.
人乳头瘤病毒（HPV）的生命周期与受感染上皮细胞的分化紧密相连。这意味着病毒蛋白必须对上皮基因表达进行调控，以优化病毒的产生。HPV E2蛋白在病毒感染生命周期中控制复制、转录和病毒基因组的分配。它由一个核酸结合结构域和一个蛋白质-蛋白质相互作用结构域组成，中间隔着一个富含丝氨酸和精氨酸的柔性铰链区。在过去几年中，越来越多的证据揭示了E2在病毒和细胞RNA加工中的重要新作用。本综述讨论了E2在控制上皮细胞环境中的作用，以及E2如何协调病毒复制周期后期事件。
