Jiang B, He Y, Zuo F, Wu L, Liu Q H, Zhang L, Zhou C X, Cheng J J, Chan Sc Z S, Lam D Q
Department of Traditional Chinese Medicine and Acupuncture, Nanlou Faculty of Clinical Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Jul 6;50(7):640-4. doi: 10.3760/cma.j.issn.0253-9624.2016.07.015.
To evaluate the effectiveness of bupropion for smoking cessation among Chinese smokers at a smoking cessation clinic.
A prospective observational study was conducted in a hospital located in Beijing during 2008 and from 28 to 31 October 2014. A total of 287 smokers (265 men and 22 women) were assessed using data from structured questionnaires at baseline and were followed up at 1 and 6 months. Trained physician counselors provided free brief education and individual counseling sessions for all participants at the first visit. A total 131 participants were prescribed bupropion in addition to counseling. The counseling plus bupropion group was compared with the group who underwent counseling without bupropion. Outcomes were self-reported 7-day point prevalence abstinence rates at 1- and 6-month follow-up and continuous abstinence rates at 6-month follow-up. Smoking reduction rates at 1 and 6 months were also measured.
By intention-to-treat analysis, the 7-day point prevalence abstinence rate of the bupropion group at 1 and 6 months was higher than for the counseling-only group: at 1-month follow-up, 26.0% (34/131) vs. 15.4% (24/156), with OR (95% CI) 1.93(1.07-3.46); these rates at 6-month follow-up were 27.8% (35/131) vs. 15.4% (24/156), with OR (95% CI) 2.01(1.12-3.59). The 1-month continuous abstinence rate at 6 months was higher in the bupropion group: 26.0% (34/131) vs. 14.7% (23/156), with OR (95%CI) 2.03(1.12-3.66). Participants in the bupropion group also had a higher smoking reduction rate at 1 month than those in the counseling-only group: 55.0% (72/131) vs. 38.5% (60/156), with OR (95%CI) 1.95 (1.22-3.13).
Prescription of bupropion at this smoking cessation clinic was effective in doubling the quitting rates and smoking reduction rates among Chinese smokers.
评估安非他酮在中国戒烟门诊帮助吸烟者戒烟的有效性。
2008年至2014年10月28日至31日期间，在北京一家医院开展了一项前瞻性观察性研究。共有287名吸烟者（265名男性和22名女性）参与研究，在基线时通过结构化问卷收集数据进行评估，并在1个月和6个月时进行随访。训练有素的医生顾问在首次就诊时为所有参与者提供免费的简短教育和个体咨询服务。共有131名参与者在接受咨询的同时还被处方了安非他酮。将咨询加安非他酮组与仅接受咨询的组进行比较。观察指标为1个月和6个月随访时自我报告的7天点患病率戒烟率以及6个月随访时的持续戒烟率。同时还测量了1个月和6个月时的吸烟减少率。
采用意向性分析，安非他酮组在1个月和6个月时的7天点患病率戒烟率高于仅接受咨询的组：在1个月随访时，分别为26.0%（34/131）和15.4%（24/156），比值比（95%可信区间）为1.93（1.07 - 3.46）；在6个月随访时，分别为27.8%（35/131）和15.4%（24/156），比值比（95%可信区间）为2.01（1.12 - 3.59）。安非他酮组在6个月时的1个月持续戒烟率更高：26.0%（34/131）和14.7%（23/156），比值比（95%可信区间）为2.03（1.12 - 3.66）。安非他酮组在1个月时的吸烟减少率也高于仅接受咨询的组：55.0%（72/131）和38.5%（60/156），比值比（95%可信区间）为1.95（1.22 - 3.13）。
在该戒烟门诊处方安非他酮可使中国吸烟者的戒烟率和吸烟减少率提高一倍，效果显著。
