Rosińczuk Joanna, Taradaj Jakub, Dymarek Robert, Sopel Mirosław
Department of Nervous System Diseases, The Faculty of Health Science, Wrocław Medical University, Bartla 5 Street, 51-618 Wroclaw, Poland.
Department of Physiotherapy Basics, Academy School of Physical Education in Katowice, Mikolowska 65 Street, 40-065 Katowice, Poland.
Biomed Res Int. 2016;2016:3943481. doi: 10.1155/2016/3943481. Epub 2016 Jun 20.
Basic and clinical studies on mechanobiology of cells and tissues point to the importance of mechanical forces in the process of skin regeneration and wound healing. These studies result in the development of new therapies that use mechanical force which supports effective healing. A better understanding of mechanobiology will make it possible to develop biomaterials with appropriate physical and chemical properties used to treat poorly healing wounds. In addition, it will make it possible to design devices precisely controlling wound mechanics and to individualize a therapy depending on the type, size, and anatomical location of the wound in specific patients, which will increase the clinical efficiency of the therapy. Linking mechanobiology with the science of biomaterials and nanotechnology will enable in the near future precise interference in abnormal cell signaling responsible for the proliferation, differentiation, cell death, and restoration of the biological balance. The objective of this study is to point to the importance of mechanobiology in regeneration of skin damage and wound healing. The study describes the influence of rigidity of extracellular matrix and special restrictions on cell physiology. The study also defines how and what mechanical changes influence tissue regeneration and wound healing. The influence of mechanical signals in the process of proliferation, differentiation, and skin regeneration is tagged in the study.
细胞和组织力学生物学的基础与临床研究表明，机械力在皮肤再生和伤口愈合过程中具有重要作用。这些研究促使了利用机械力支持有效愈合的新疗法的发展。对力学生物学的更深入理解将有助于开发具有适当物理和化学性质的生物材料，用于治疗愈合不良的伤口。此外，还能够设计精确控制伤口力学的装置，并根据特定患者伤口的类型、大小和解剖位置进行个性化治疗，从而提高治疗的临床效率。将力学生物学与生物材料科学和纳米技术相结合，在不久的将来将能够对负责细胞增殖、分化、细胞死亡和生物平衡恢复的异常细胞信号进行精确干预。本研究的目的是指出力学生物学在皮肤损伤再生和伤口愈合中的重要性。该研究描述了细胞外基质刚度和特殊限制对细胞生理学的影响。该研究还确定了机械变化如何以及何种机械变化影响组织再生和伤口愈合。该研究标记了机械信号在增殖、分化和皮肤再生过程中的影响。
