青少年慢性粒细胞白血病红系祖细胞阶段促红细胞生成素依赖性红细胞生成
Erythropoietin dependent erythropoiesis during the erythroblastic phase of juvenile chronic granulocytic leukaemia.
作者信息
Hoffman R, Zanjani E D
出版信息
Br J Haematol. 1978 Apr;38(4):511-6. doi: 10.1111/j.1365-2141.1978.tb01076.x.
Abstract
A child aged 3 1/2 years with typical juvenile chronic granulocytic leukaemia whose course terminated in an erythroblastic phase is described. Both in-vivo transfusion studies and in-vitro bone marrow culture studies indicate that red cell production remains erythropoietin dependent in this situation. The relationship of erythropoietin to the reversion to fetal haematopoiesis which characterizes juvenile chronic granulocytic leukaemia is discussed.
摘要
本文描述了一名3岁半患典型青少年慢性粒细胞白血病的儿童，其病程以红系阶段告终。体内输血研究和体外骨髓培养研究均表明，在这种情况下红细胞生成仍依赖促红细胞生成素。文中讨论了促红细胞生成素与青少年慢性粒细胞白血病所特有的向胎儿造血逆转之间的关系。
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