三氟甲硫基作为三氟甲基化试剂用于末端烯烃的邻位双官能团化。
TfNHNHBoc as a Trifluoromethylating Agent for Vicinal Difunctionalization of Terminal Alkenes.
机构信息
Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, China.
出版信息
Org Lett. 2016 Aug 5;18(15):3850-3. doi: 10.1021/acs.orglett.6b01862. Epub 2016 Jul 14.
An unprecedented application of trifluoromethanesulfonyl hydrazides as trifluoromethylating agents has been demonstrated in two vicinal difunctionalization reactions of terminal alkenes: the copper-catalyzed three-component vicinal chlorotrifluoromethylation of arylakenes with TfNHNHBoc and NaCl and the tandem trifluoromethylation/cyclization of N-arylacrylamides with TfNHNHBoc. The reactions proceeded in the presence of inexpensive oxidants under mild conditions and provided a range of structurally diverse trifluoromethyl-containing compounds with high regioselectivity.
三氟甲磺酰基叠氮化物在末端烯烃的两个相邻双官能化反应中得到了前所未有的应用
铜催化的芳基烯烃与 TfNHNHBoc 和 NaCl 的邻位氯三氟甲基化的三组分反应，以及 TfNHNHBoc 的 N-芳基丙烯酰胺的串联三氟甲基化/环化反应。这些反应在温和条件下、使用廉价氧化剂进行，提供了一系列具有高区域选择性的结构多样的含三氟甲基化合物。
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