Pirttiaho H
Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):271-6.
Liver size, cytochrome P-450 (P-450) concentration in liver biopsy specimens and antipyrine kinetics were studied in 112 consecutive patients undergoing diagnostic liver biopsy. Compared to subjects with normal parenchyma, those with slight or severe parenchymal alterations had enlarged livers with low P-450 concentration and slow antipyrine elimination. In the normal group, the mean P-450 concentration (+/- 1 SD) was 11.10 +/- 2.14 nmol/g liver tissue and the total amount (estimated liver weight g X P-450 concentration nmol/g) 16.06 +/- 3.29 mumol. Previous therapy with enzyme inducing drugs was associated with enlarged liver in subjects with normal histological findings and with fast antipyrine elimination and high P-450 in all groups. Antipyrine elimination rate correlated with liver weight only in subjects with normal parenchyma. The total amount of P-450 was generally more closely related to its concentration than to the estimated liver weight, although in many individual cases a large liver was able to compensate a low P-450 concentration so that the total P-450 was at the normal level. Despite normal or high total P-450, in vivo drug metabolism was impaired in subjects with altered parenchyma, suggesting that other factors were limiting antipyrine elimination in liver disease.
对112例接受诊断性肝活检的连续患者进行了肝脏大小、肝活检标本中细胞色素P - 450（P - 450）浓度及安替比林动力学研究。与实质正常的受试者相比，实质有轻度或重度改变的受试者肝脏增大，P - 450浓度降低，安替比林消除缓慢。正常组中，肝组织P - 450平均浓度（±1标准差）为11.10±2.14 nmol/g，总量（估计肝脏重量g×P - 450浓度nmol/g）为16.06±3.29 μmol。既往使用酶诱导药物治疗与组织学表现正常的受试者肝脏增大、所有组中安替比林快速消除及P - 450升高有关。仅在实质正常的受试者中，安替比林消除率与肝脏重量相关。P - 450总量一般与其浓度的关系比与估计肝脏重量的关系更密切，尽管在许多个体病例中，大肝脏能够补偿低P - 450浓度，使P - 450总量处于正常水平。尽管P - 450总量正常或升高，但实质改变的受试者体内药物代谢受损，提示其他因素限制了肝病患者安替比林的消除。
