Heddle N M
a Department of Pathology , McMaster University and Laboratory Medicine, Hamilton Health Sciences Corporation , Hamilton , Ontario , Canada.
Hematology. 1997;2(6):473-84. doi: 10.1080/10245332.1997.11746369.
There are many cytokines that have been shown to increase in platelet concentrates during storage including: proinflammatory cytokines, chemokines, and transforming growth factor β. The concentrations of these cytokines can be variable depending on the method of platelet preparation, and the leukocyte and/or platelet concentration in the product. The clinical significance of these cytokines is questionable; however, clinical data suggests that tike proinflammatory cytokines may play an important role in causing febrile non-hemolytic transfusion reactions. The clinical data to support a causative role in these reactions includes: correlational studies where high concentrations of proinflammatory cytokines were associated with a higher frequency of reactions; observational studies showing that the transfusion of platelet products with high leukocyte counts have a higher likelihood of causing reactions; and, experimental studies where products with low cytokine levels seldom cause FNHTR. The clinical relevance of chemokines and other growth factors detected in platelet concentrates remains inconclusive.
已有许多细胞因子被证明在血小板浓缩物储存期间会增加，包括：促炎细胞因子、趋化因子和转化生长因子β。这些细胞因子的浓度会因血小板制备方法以及产品中的白细胞和/或血小板浓度而有所不同。这些细胞因子的临床意义尚不确定；然而，临床数据表明，诸如促炎细胞因子可能在引起发热性非溶血性输血反应中起重要作用。支持其在这些反应中起因果作用的临床数据包括：相关性研究，其中促炎细胞因子高浓度与更高的反应频率相关；观察性研究表明，输注白细胞计数高的血小板产品更有可能引起反应；以及实验研究，其中细胞因子水平低的产品很少引起发热性非溶血性输血反应。在血小板浓缩物中检测到的趋化因子和其他生长因子的临床相关性仍无定论。
