特发性血小板减少性紫癜和再生障碍性贫血患者血浆中血小板衍生生长因子的进展活性。

Progression activity for platelet-derived growth factor in plasma of patients with idiopathic thrombocytopenic purpura and aplastic anemia.

作者信息

Katoh O, Kimura A, Fujimura K, Kuramoto A

出版信息

Nihon Ketsueki Gakkai Zasshi. 1989 Feb;52(1):113-7.

Abstract

Progression activity for competence induced by platelet-derived growth factor (PDGF) was measured in plasma of patients with idiopathic thrombocytopenic purpura (ITP) and aplastic anemia (AA), in order to clarify the mechanism operating to maintain the wound healing system of these chronically thrombocytopenic patients. Progression activity in both ITP and AA patients was significantly higher than in normal subjects. There was a positive correlation between the activity and the duration of thrombocytopenia in AA patients who had thrombocytopenia for less than 100 months. The level of insulin like growth factor-I (IGF-I), which is a progression factor for PDGF, was lower in patients, than in normal controls. These results suggest that some plasma progression factor(s) for PDGF, other than IGF-I, plays an important role in maintaining the wound healing system of blood vessels in chronically thrombocytopenic patients.

摘要

为了阐明维持这些慢性血小板减少症患者伤口愈合系统的作用机制，对特发性血小板减少性紫癜（ITP）和再生障碍性贫血（AA）患者血浆中由血小板衍生生长因子（PDGF）诱导的增殖活性进行了测定。ITP和AA患者的增殖活性均显著高于正常受试者。在血小板减少持续时间少于100个月的AA患者中，该活性与血小板减少持续时间呈正相关。作为PDGF增殖因子的胰岛素样生长因子-I（IGF-I）水平在患者中低于正常对照组。这些结果表明，除IGF-I外，某些PDGF的血浆增殖因子在维持慢性血小板减少症患者血管的伤口愈合系统中起重要作用。