Sylwestrowicz T A, Sokołowska K
Haematologia (Budap). 1978;12(1-4):189-97.
By means of a bioassay performed in rats utilizing 75Se-selenomethionine as a platelet marker in vivo, serum thrombocytopoietic activity (STA) was determined in 9 healthy volunteers and in 82 patients with thrombocytopenia, viz. 27 cases of ITP (9 acute and 18 chronic), 19 of aplastic anaemia, 19 of acute leukaemia and 17 of chronic proliferative disorders. STA was the highest in the ITP group (p less than 0.01), particularly in the cases of short duration (p less than 0.001). In acute leukaemia, the STA was remarkably elevated (p less than 0.02) and a negative correlation between STA and blood platelet count could be demonstrated. A negative correlation between STA and the duration of thrombocytopenia was also found in the patients with ITP. No significant increase of STA was observed in patients with ITP after corticosteroid administration. In 5 out of 7 cases who responded satisfactorily to splenectomy a significant fall of STA was demonstrated after surgery. A slight, but statistically significant, rise of the STA value was found in patients with aplastic anaemia (p less than 0.05). No STA elevation was observed in the cases of chronic proliferative disorders with thrombocytopenia.
通过在大鼠体内进行生物测定，以75Se - 硒蛋氨酸作为血小板标记物，测定了9名健康志愿者和82名血小板减少症患者的血清血小板生成活性（STA），这些患者包括27例特发性血小板减少性紫癜（ITP）（9例急性和18例慢性）、19例再生障碍性贫血、19例急性白血病和17例慢性增殖性疾病。ITP组的STA最高（p < 0.01），尤其是病程短的病例（p < 0.001）。在急性白血病中，STA显著升高（p < 0.02），并且STA与血小板计数之间呈负相关。在ITP患者中也发现STA与血小板减少持续时间呈负相关。ITP患者在使用皮质类固醇后未观察到STA有明显增加。在7例脾切除术后反应良好的患者中，有5例术后STA显著下降。再生障碍性贫血患者的STA值有轻微但具有统计学意义的升高（p < 0.05）。血小板减少的慢性增殖性疾病患者未观察到STA升高。
