Tishevskaya N V
Eksp Klin Farmakol. 2016;79(2):24-8.
The study performed on erythroblastic island cultures and rats with experimental polycythemia showed that recormon and epokrin stimulated erythropoiesis in erythroblastic islands both in vitro and in vivo. In cell cultures, recormon activates the formation of erythroblastic islands de novo and de repeto 1.3 times better than epokrin (p < 0.05). Erythroid cells exbhibited same reaction to epokrin and recormon in vivo: the number of erythroblastic islands in the bone marrow increased 3.4 times (p < 0.05) and the number of reticulocytes in the blood increased 2.2 times (p < 0.05).
对成红细胞岛培养物和实验性红细胞增多症大鼠进行的研究表明，重组促红细胞生成素和依泊汀在体外和体内均能刺激成红细胞岛中的红细胞生成。在细胞培养中，重组促红细胞生成素比依泊汀更能从头和反复激活成红细胞岛的形成，效果要好1.3倍（p < 0.05）。在体内，红系细胞对依泊汀和重组促红细胞生成素表现出相同的反应：骨髓中成红细胞岛的数量增加了3.4倍（p < 0.05），血液中网织红细胞的数量增加了2.2倍（p < 0.05）。
