实验性苯诱导贫血时骨髓幼红细胞岛中红细胞生成的动力学

Dynamics of Erythropoiesis in Erythroblastic Islands in the Bone Marrow in Experimental Benzene-Induced Anemia.

作者信息

Tishevskaya N V, Bolotov A A, Lebedeva Ya E

机构信息

South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.

出版信息

Bull Exp Biol Med. 2016 Jul;161(3):384-7. doi: 10.1007/s10517-016-3420-4. Epub 2016 Aug 5.

DOI:10.1007/s10517-016-3420-4

PMID:27492403

Abstract

In 14 days after triple subcutaneous injection of benzene to rats in a dose of 0.05 ml/100 g body weight, the number of erythroblastic islands in the bone marrow 2-fold decreased, de novo erythropoiesis ceased, de repeto erythropoiesis slowed down, and the number of lymphoid cells contacting with erythroblastic islands decreased. By day 56 of the experiment, proliferation of erythroid cells in the bone marrow start to recover due to erythropoiesis reconstitution, but the number of reticulocytes in the blood remained low. Analysis of phagocytic ability of macrophages in the erythroblastic islands showed that the intensity of phagocytosis of latex particles in mature islands decreased, which could affect denucleation of oxyphilic erythroblasts.

摘要

给大鼠皮下注射剂量为0.05 ml/100 g体重的苯，连续三次注射后14天，骨髓中红细胞岛数量减少了两倍，新生红细胞生成停止，重复性红细胞生成减缓，与红细胞岛接触的淋巴细胞数量减少。到实验第56天，由于红细胞生成重建，骨髓中红系细胞增殖开始恢复，但血液中网织红细胞数量仍然很低。对红细胞岛中巨噬细胞吞噬能力的分析表明，成熟岛中乳胶颗粒的吞噬强度降低，这可能影响嗜酸性成红细胞的去核。