Maiovis Pantelis, Ioannidis Panagiotis, Gerasimou Georgios, Gotzamani-Psarrakou Anna, Karacostas Dimitrios
From the B Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (PM, PI, DK); and the B Laboratory of Nuclear Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (GG, A G-P).
J Neuropsychiatry Clin Neurosci. 2017 Winter;29(1):26-30. doi: 10.1176/appi.neuropsych.16020034. Epub 2016 Jul 15.
Severity assessment scales for frontotemporal lobar degeneration (FTLD) have been recently introduced. In the present study, the authors examined whether the FTLD-modified Clinical Dementia Rating (FTLD-CDR) scale and the Frontotemporal Dementia Rating Scale (FRS) correlated with regional brain perfusion in Greek FTLD patients. A total of 47 behavioral variant frontotemporal dementia (bvFTD) patients and 33 primary progressive aphasia (PPA) patients were assessed for demographic data, cognitive reserve (CR), and severity of dementia and underwent brain single-photon emission computed tomography. Both scales were valid in the bvFTD group, predicting frontal lobe perfusion. In the PPA group, both scales were found to predict temporal hypoperfusion only after accounting for CR, which could imply a potential role for reserve in PPA patients.
最近引入了额颞叶变性（FTLD）的严重程度评估量表。在本研究中，作者检查了FTLD改良临床痴呆评定量表（FTLD-CDR）和额颞叶痴呆评定量表（FRS）是否与希腊FTLD患者的脑区灌注相关。共对47例行为变异型额颞叶痴呆（bvFTD）患者和33例原发性进行性失语（PPA）患者进行了人口统计学数据、认知储备（CR）和痴呆严重程度评估，并接受了脑单光子发射计算机断层扫描。两种量表在bvFTD组中均有效，可预测额叶灌注。在PPA组中，仅在考虑CR后发现两种量表均可预测颞叶灌注不足，这可能意味着储备在PPA患者中具有潜在作用。
