Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Alzheimers Dement. 2020 Jun;16(6):918-925. doi: 10.1002/alz.12098. Epub 2020 May 13.
The Frontotemporal Lobar Degeneration Module (FTLD-MOD) was designed as a research neuropsychological battery to evaluate clinical symptoms associated with FTLD. This study investigated whether the FTLD-MOD could differentiate between primary progressive aphasia (PPA) and behavioral variant frontotemporal dementia (bvFTD), two distinct FTLD-related syndromes.
Retrospective analysis was conducted on data collected from the initial visit of 165 subjects with PPA, 268 with bvFTD, and 251 cognitively normal controls from the National Alzheimer's Coordinating Center. Generalized linear models were used to compare group performance patterns on FTLD-MOD tasks of language, behavior, and memory.
PPA participants showed significantly poorer performances on all language tasks whereas bvFTD participants demonstrated poorer performances on most behavioral measures. There were no differences in memory performances. Descriptive data on participant groups are provided for reference.
Findings from this multi-center sample suggest that the FTLD-MOD can differentiate between distinctive clinical phenotypes commonly associated with FTLD.
额颞叶变性模块（FTLD-MOD）是作为一种研究性神经心理学测试工具而设计的，用于评估与额颞叶变性（FTLD）相关的临床症状。本研究旨在探究 FTLD-MOD 是否能够区分原发性进行性失语症（PPA）和行为变异额颞叶痴呆（bvFTD），这两种不同的 FTLD 相关综合征。
对来自国家阿尔茨海默病协调中心的 165 名 PPA 患者、268 名 bvFTD 患者和 251 名认知正常对照者的初始就诊数据进行了回顾性分析。采用广义线性模型比较了 FTLD-MOD 语言、行为和记忆任务中各组的表现模式。
PPA 患者在所有语言任务中的表现明显较差，而 bvFTD 患者在大多数行为测量中表现较差。记忆表现无差异。为方便参考，为参与者群体提供了描述性数据。
来自多中心样本的研究结果表明，FTLD-MOD 可以区分与 FTLD 相关的独特临床表型。
