Kato Y, Auer L M
Department of Neurosurgery, University of Graz, Austria.
Acta Neurochir (Wien). 1989;98(3-4):184-8. doi: 10.1007/BF01407346.
The behaviour of Pial vessels to levels of CSF-pressure between 10 and 100 mmHg induced by vetricular infusion of mock CSF, was observed in 6 cats under barbiturate and N2O anaesthesia, using the cranial window technique and videoangiometry. Supratentorial pressure (STP) equaled infratentorial pressure in the cisterna magna (CMP) throughou. No changes in pial arterial calibres were noted up to a CMP of 13 mmHg (i.e. a cerebral perfusion pressure (CPP) of 100 mmHg). Further increase of CMP to 45 mmHg induced significant arterial dilatation of 40 +/- 3.4%. With a further rise of ventricular fluid pressure (VFP) no marked further arterial dilatation occurred. Dilatation of arteries up to 100 um resting diameter and arteries between 100 and 250 um resting diameter and arteries between 100 and 250 um was not significantly different. When CPP approached 40 mmHg, arteries were still 47 +/- 3.6% dilated. Pial venous calibre did not vary by more than 20% during elevation of VFP. At CPP 47 mmHg, small and large veins were dilated by 14%. Single venous segments were compressed by crossing pial arteries and caused upstream venous congestion and distension.
在6只接受巴比妥酸盐和一氧化二氮麻醉的猫中，采用颅骨开窗技术和视频血管造影术，观察了通过向脑室注入模拟脑脊液使脑脊液压力在10至100 mmHg之间变化时软脑膜血管的行为。幕上压力（STP）在整个过程中与枕大池压力（CMP）相等。在CMP达到13 mmHg（即脑灌注压（CPP）为100 mmHg）之前，未观察到软脑膜动脉管径有变化。CMP进一步升高至45 mmHg时，动脉出现显著扩张，扩张幅度为40±3.4%。随着脑室液压力（VFP）进一步升高，动脉未出现明显的进一步扩张。直径达100μm的静息动脉、直径在100至250μm之间的动脉以及直径在100至250μm之间的动脉的扩张情况无显著差异。当CPP接近40 mmHg时，动脉仍扩张47±3.6%。在VFP升高期间，软脑膜静脉管径变化不超过20%。在CPP为47 mmHg时，小静脉和大静脉均扩张14%。单个静脉段被交叉的软脑膜动脉压迫，导致上游静脉充血和扩张。
