Hooper Robert, Zaidi M Raza, Soboloff Jonathan
Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, 19140, USA.
Department of Medical Genetics & Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, 19140, USA.
Sci China Life Sci. 2016 Aug;59(8):764-9. doi: 10.1007/s11427-016-5087-5. Epub 2016 Jul 14.
Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease.
钙是许多在癌症中受到干扰的生理过程的关键调节因子，如迁移、增殖和凋亡。STIM和Orai蛋白介导钙库操纵的钙内流（SOCE），这是非兴奋性细胞中钙内流的主要途径。在一系列癌症类型中发现了STIM和Orai的表达及功能变化，因此与疾病进展有关。在这里，我们讨论STIM、Orai和SOCE途径在黑色素瘤进展中的作用，并探讨黑色素瘤的异质性如何解释该领域关于SOCE在这种疾病进展中的作用缺乏共识的情况。
