Tonk Miray, Vilcinskas Andreas, Rahnamaeian Mohammad
LOEWE Center for Insect Biotechnology and Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Winchester Strasse, 35394, Giessen, Germany.
Institute for Insect Biotechnology, Justus Liebig University of Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
Appl Microbiol Biotechnol. 2016 Sep;100(17):7397-405. doi: 10.1007/s00253-016-7718-y. Epub 2016 Jul 15.
Antimicrobial peptides/proteins (AMPs) are biologically active molecules with diverse structural properties that are produced by mammals, plants, insects, ticks, and microorganisms. They have a range of antibacterial, antifungal, antiviral, and even anticancer activities, and their biological properties could therefore be exploited for therapeutic and prophylactic applications. Cancer and cancer drug resistance are significant current health challenges, so the development of innovative cancer drugs with minimal toxicity toward normal cells and novel modes of action that can evade resistance may provide a new direction for anticancer therapy. The skin is the first line of defense against heat, sunlight, injury, and infection, and skin cancer is thus the most common type of cancer. The skin that has been exposed to sunlight is particularly susceptible, but lesions can occur anywhere on the body. Skin cancer awareness and self-efficacy are necessary to improve sun protection behavior, but more effective preventative approaches are also required. AMPs may offer a new prophylactic approach against skin cancer. In this mini review, we draw attention to the potential use of insect AMPs for the prevention and treatment of skin cancer.
抗菌肽/蛋白质（AMPs）是具有多种结构特性的生物活性分子，由哺乳动物、植物、昆虫、蜱虫和微生物产生。它们具有一系列抗菌、抗真菌、抗病毒甚至抗癌活性，因此其生物学特性可用于治疗和预防应用。癌症和癌症耐药性是当前重大的健康挑战，因此开发对正常细胞毒性最小且能规避耐药性的新型作用模式的创新抗癌药物可能为抗癌治疗提供新方向。皮肤是抵御热、阳光、损伤和感染的第一道防线，因此皮肤癌是最常见的癌症类型。暴露于阳光下的皮肤特别容易患病，但身体任何部位都可能出现病变。提高皮肤癌意识和自我效能对于改善防晒行为是必要的，但也需要更有效的预防方法。AMPs可能为皮肤癌提供一种新的预防方法。在本综述中，我们提请注意昆虫AMPs在皮肤癌预防和治疗中的潜在用途。
