N-乙酰半胱氨酸对血液透析患者血清氧化生物标志物的影响。
The effect of N-acetylcysteine on oxidative serum biomarkers of hemodialysis patients.
作者信息
Giannikouris I
机构信息
Hemodialysis Unit, Ilion Medical Nursery, Medifil, Athens, Greece.
出版信息
Hippokratia. 2015 Apr-Jun;19(2):131-5.
BACKGROUND
The aim of the study was to determine the effect of oral N-acetylcysteine (NAC) on levels of serum oxidative stress biomarkers in hemodialysis patients.
METHODS
Forty eight hemodialysis patients were administered NAC orally for six months. Hematological, biochemical parameters and levels of asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), myeloperoxidase (MPO) and nitrogen oxide (NO) were determined prior to and upon completion of the study period.
RESULTS
At the end of the study period white blood cells, neutrophil percentage and C-reactive protein levels were significantly lower. Uric acid, albumin and hemoglobin were significantly higher compared to pre-treatment values. Statistically significant increase in NO, and decrease in MDA and ADMA levels were observed. Serum MPO demonstrated a measurable decrease trend, though not significant.
CONCLUSION
It is suggested that treatment with NAC appears to be associated with restoration of important parameters of antioxidant defence and reduction in the levels of mediators of oxidative cellular damage. Hippokratia 2015; 19 (2):131-135.
背景
本研究旨在确定口服N-乙酰半胱氨酸（NAC）对血液透析患者血清氧化应激生物标志物水平的影响。
方法
48例血液透析患者口服NAC六个月。在研究期开始前和结束时测定血液学、生化参数以及不对称二甲基精氨酸（ADMA）、丙二醛（MDA）、髓过氧化物酶（MPO）和氮氧化物（NO）的水平。
结果
在研究期末，白细胞、中性粒细胞百分比和C反应蛋白水平显著降低。与治疗前相比，尿酸、白蛋白和血红蛋白显著升高。观察到NO有统计学意义的升高，MDA和ADMA水平降低。血清MPO呈现出可测量的下降趋势，尽管不显著。
结论
提示NAC治疗似乎与抗氧化防御重要参数的恢复以及氧化细胞损伤介质水平的降低有关。《希波克拉底》2015年；19（2）：131 - 135。
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