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本文引用的文献

1
Purification and comparison of intracellular proteinase A in Candida spp. isolates from Malaysian and Iranian patients and infected mice.从马来西亚和伊朗患者及感染小鼠中分离的念珠菌属内蛋白水解酶 A 的纯化及比较。
J Mycol Med. 2012 Jun;22(2):149-59. doi: 10.1016/j.mycmed.2012.01.002. Epub 2012 Feb 24.
2
Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry.绘制白念珠菌 Hsp90 遗传互作网络图谱揭示了环境偶然性和重布线的电路。
PLoS Genet. 2012;8(3):e1002562. doi: 10.1371/journal.pgen.1002562. Epub 2012 Mar 15.
3
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.热休克蛋白 90 和环境压力改变了自然遗传变异的适应性价值。
Science. 2010 Dec 24;330(6012):1820-4. doi: 10.1126/science.1195487.
4
Candida infection and colonization among trauma patients.创伤患者中的念珠菌感染和定植。
Virulence. 2010 Sep-Oct;1(5):367-75. doi: 10.4161/viru.1.5.12796.
5
Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms.蛋白质平衡和遗传多样性的表型表现：原理和机制。
Annu Rev Genet. 2010;44:189-216. doi: 10.1146/annurev.genet.40.110405.090412.
6
PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.PKC 信号通过由 Mkc1、钙调神经磷酸酶和 Hsp90 组成的电路调节真菌病原体白念珠菌的耐药性。
PLoS Pathog. 2010 Aug 26;6(8):e1001069. doi: 10.1371/journal.ppat.1001069.
7
Hsp90 orchestrates stress response signaling governing fungal drug resistance.热休克蛋白90（Hsp90）协调控制真菌耐药性的应激反应信号传导。
PLoS Pathog. 2009 Aug;5(8):e1000471. doi: 10.1371/journal.ppat.1000471. Epub 2009 Aug 28.
8
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling.热休克蛋白90通过Ras1-蛋白激酶A信号传导调控白色念珠菌的温度依赖性形态发生。
Curr Biol. 2009 Apr 28;19(8):621-9. doi: 10.1016/j.cub.2009.03.017. Epub 2009 Mar 26.
9
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.利用热休克蛋白90（Hsp90）的功能作为一种强大且广泛有效的治疗真菌传染病的策略。
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2818-23. doi: 10.1073/pnas.0813394106. Epub 2009 Feb 5.
10
The stress responsive and morphologically regulated hsp90 gene from Paracoccidioides brasiliensis is essential to cell viability.来自巴西副球孢子菌的应激反应性和形态学调控的热休克蛋白90（hsp90）基因对细胞活力至关重要。
BMC Microbiol. 2008 Sep 22;8:158. doi: 10.1186/1471-2180-8-158.

从马来西亚和伊朗患者分离的白色念珠菌热休克蛋白90（Hsp90）的差异基因表达

Differential Gene Expression of Heat Shock Protein 90 (Hsp90) of Candida albicans obtained from Malaysian and Iranian Patients.

作者信息

Khalili Vajihe, Shokri Hojjatollah, Md Akim Abdah, Khosravi Ali Reza

机构信息

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Department of Pathobiology, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, 24th Aftab, Imam Khomeini Street 46168- 49767, Amol, Iran.

出版信息

Malays J Med Sci. 2016 May;23(3):64-71.

PMID:27418871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4934720/
Abstract

BACKGROUND

Candida albicans (C. albicans) has several virulence factors, in particular heat shock protein 90 (Hsp90), which is expressed by Hsp90 gene. The purposes of this study were to assess the expression of Hsp90 gene in clinical and control isolates of C. albicans obtained from different geographical regions (Malaysia and Iran), different temperatures (25°C, 37°C and 42°C) and mice with candidiasis.

METHODS

C. albicans isolates were cultured onto sabouraud dextrose agar (SDA). The assessment of the expression of Hsp90 gene was performed using real time-polymerase chain reaction (RT-PCR).

RESULTS

The results showed a significant increase in the expression of C. albicans Hsp90 gene under high thermal shock (42°C) when compared to other temperatures tested (P-value = 0.001). The mean differences in the expression of Hsp90 gene at 37°C were 0.20 (95% confidence interval (CI) 0.13-0.29) between Malaysian and Iranian controls (P-value = 0.040) and 0.47 (95% CI 0.27-0.60) between Malaysian and Iranian patients (P-value = 0.040).

CONCLUSION

The results demonstrated that the expression of C. albicans Hsp90 gene varied between Malaysian and Iranian subjects, representing the efficacy of geographical and thermal conditions on virulence gene expression.

摘要

背景

白色念珠菌具有多种毒力因子，尤其是热休克蛋白90（Hsp90），其由Hsp90基因表达。本研究的目的是评估Hsp90基因在从不同地理区域（马来西亚和伊朗）、不同温度（25°C、37°C和42°C）以及患念珠菌病的小鼠中获得的白色念珠菌临床分离株和对照分离株中的表达情况。

方法

将白色念珠菌分离株接种于沙保弱葡萄糖琼脂（SDA）上。使用实时聚合酶链反应（RT-PCR）对Hsp90基因的表达进行评估。

结果

结果显示，与其他测试温度相比，白色念珠菌Hsp90基因在高热休克（42°C）条件下的表达显著增加（P值 = 0.001）。马来西亚和伊朗对照之间在37°C时Hsp90基因表达的平均差异为0.20（95%置信区间（CI）0.13 - 0.29）（P值 = 0.040），马来西亚和伊朗患者之间为0.47（95% CI 0.27 - 0.60）（P值 = 0.040）。

结论

结果表明，白色念珠菌Hsp90基因的表达在马来西亚和伊朗受试者之间存在差异，这体现了地理和温度条件对毒力基因表达的影响。