Guzman David Calderón, Olguín Hugo Juárez, García Ernestina Hernández, Peraza Armando Valenzuela, de la Cruz Diego Zamora, Soto Monica Punzo
a Laboratory of Neurochemistry , National Institute of Pediatrics , Mexico.
b Laboratory of Pharmacology , National Institute of Pediatrics , Mexico.
Redox Rep. 2017 Jan;22(1):10-16. doi: 10.1080/13510002.2016.1205303. Epub 2016 Jul 15.
Diabetic retinopathy (DR) is one of the main complications in patients with diabetes and has been the leading cause of visual loss since 1990. Oxidative stress is a biological process resulting from excessive production of reactive oxygen species (ROS). This process contributes to the development of many diseases and disease complications. ROS interact with various cellular components to induce cell injury. Fortunately, there is an antioxidan t system that protects organisms against ROS. Indeed, when ROS exceed antioxidant capacity, the resulting cell injury can cause diverse physiological and pathological changes that could lead to a disease like DR.
This paper reviews the possible mechanisms of common and novel biomarkers involved in the development of DR and explores how these biomarkers could be used to monitor the damage induced by oxidative stress in DR, which is a significant complication in people with diabetes.
The poor control of glucemy in pacients with DB has been shown contribute to the development of complications in eyes as DR.
糖尿病视网膜病变（DR）是糖尿病患者的主要并发症之一，自1990年以来一直是视力丧失的主要原因。氧化应激是一种由活性氧（ROS）过量产生导致的生物学过程。这一过程促使许多疾病及其并发症的发展。ROS与各种细胞成分相互作用以诱导细胞损伤。幸运的是，存在一个抗氧化系统来保护生物体免受ROS的侵害。实际上，当ROS超过抗氧化能力时，由此产生的细胞损伤会导致各种生理和病理变化，进而可能引发像DR这样的疾病。
本文综述了参与DR发生发展的常见和新型生物标志物的可能机制，并探讨这些生物标志物如何用于监测糖尿病患者这一重大并发症DR中氧化应激诱导的损伤。
已表明糖尿病患者血糖控制不佳会促使眼部并发症如DR的发生。
