Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan
Department of Orthopaedic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Bone Joint Res. 2016 Jul;5(7):294-300. doi: 10.1302/2046-3758.57.BJR-2016-0057.R1.
The purpose of this study was to clarify the appearance of the reparative tissue on the articular surface and to analyse the properties of the reparative tissue after hemicallotasis osteotomy (HCO) using MRI T1ρ and T2 mapping.
Coronal T1ρ and T2 mapping and three-dimensional gradient-echo images were obtained from 20 subjects with medial knee osteoarthritis. We set the regions of interest (ROIs) on the full-thickness cartilage of the medial femoral condyle (MFC) and medial tibial plateau (MTP) of the knee and measured the cartilage thickness (mm) and T1ρ and T2 relaxation times (ms). Statistical analysis of time-dependent changes in the cartilage thickness and the T1ρ and T2 relaxation times was performed using one-way analysis of variance, and Scheffe's test was employed for post hoc multiple comparison.
The cartilage-like repair tissue appeared on the cartilage surface of the medial compartment post-operatively, and the cartilage thickness showed a significant increase between the pre-operative and one-year post-operative time points (MFC; p = 0.003, MTP; p < 0.001). The T1ρ values of the cartilage-like repair tissue showed no difference over time, however, the T2 values showed a significant decrease between the pre-operative and one-year post-operative time points (MFC; p = 0.004, MTP; p = 0.040).
This study clarified that the fibrocartilage-like repair tissue appeared on the articular surface of the medial compartment after HCO as evidenced by MRI T1ρ and T2 mapping.Cite this article: H. Nishioka, E. Nakamura, J. Hirose, N. Okamoto, S. Yamabe, H. Mizuta. MRI T1ρ and T2 mapping for the assessment of articular cartilage changes in patients with medial knee osteoarthritis after hemicallotasis osteotomy. Bone Joint Res 2016;5:294-300. DOI: 10.1302/2046-3758.57.BJR-2016-0057.R1.
本研究旨在通过 MRI T1ρ 和 T2 图谱分析，阐明膝关节内侧半骺板阻滞（HCO）术后关节表面修复组织的外观，并分析修复组织的特性。
对 20 例内侧膝关节骨关节炎患者进行冠状位 T1ρ 和 T2 图谱及三维梯度回波成像。我们在膝关节内侧股骨髁（MFC）和内侧胫骨平台（MTP）的全层软骨上设置感兴趣区（ROI），并测量软骨厚度（mm）和 T1ρ 和 T2 弛豫时间（ms）。采用单因素方差分析对软骨厚度和 T1ρ、T2 弛豫时间的时间依赖性变化进行统计学分析，并用 Scheffe 检验进行事后多重比较。
术后内侧间室软骨表面出现类似软骨的修复组织，软骨厚度在术前和术后 1 年时间点有显著增加（MFC；p = 0.003，MTP；p < 0.001）。然而，T1ρ 值在时间上没有差异，而 T2 值在术前和术后 1 年时间点有显著降低（MFC；p = 0.004，MTP；p = 0.040）。
本研究通过 MRI T1ρ 和 T2 图谱证实，HCO 后内侧间室关节表面出现纤维软骨样修复组织。
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