Malavasi Lais M, Greene Stephen A, Gay John M, Grubb Tammy L
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
J Am Assoc Lab Anim Sci. 2016;55(4):431-5.
Lidocaine is commonly used in ruminants but has an anecdotal history of being toxic to goats. To evaluate lidocaine's effects on selected cardiopulmonary parameters. Isoflurane-anesthetized adult goats (n = 24) undergoing abdominal surgery received a loading dose of lidocaine (2.5 mg/kg) over 20 min followed by constant-rate infusion of lidocaine (100 μg/kg/min); control animals received saline instead of lidocaine. Data collected at predetermined time points during the 60-min surgery included heart rate, mean arterial blood pressure, pO2, and pCO2. According to Welch 2-sample t tests, cardiopulmonary variables did not differ between groups. For example, after administration of the loading dose, goats in the lidocaine group had a mean heart rate of 88 ± 28 bpm, mean arterial blood pressure of 70 ± 19 mm Hg, pCO2 of 65 ± 13 mm Hg, and pO2 of 212 ± 99 mm Hg; in the saline group, these values were 90 ± 16 bpm, 76 ± 12 mm Hg, 61 ± 9 mm Hg, and 209 ± 83 mm Hg, respectively. One goat in the saline group required an additional dose of butorphanol. Overall our findings indicate that, at the dose provided, intravenous lidocaine did not cause adverse cardiopulmonary effects in adult goats undergoing abdominal surgery. Adding lidocaine infusion during general anesthesia is an option for enhancing transoperative analgesia in goats.
利多卡因常用于反刍动物，但有传闻称其对山羊有毒性。为评估利多卡因对选定心肺参数的影响，对接受腹部手术的异氟烷麻醉成年山羊（n = 24）先在20分钟内给予负荷剂量的利多卡因（2.5毫克/千克），随后以恒定速率输注利多卡因（100微克/千克/分钟）；对照动物接受生理盐水而非利多卡因。在60分钟手术期间的预定时间点收集的数据包括心率、平均动脉血压、pO2和pCO2。根据韦尔奇两样本t检验，两组之间的心肺变量无差异。例如，给予负荷剂量后，利多卡因组山羊的平均心率为88±28次/分钟，平均动脉血压为70±19毫米汞柱，pCO2为65±13毫米汞柱，pO2为212±99毫米汞柱；生理盐水组的这些值分别为90±16次/分钟、76±12毫米汞柱、61±9毫米汞柱和209±83毫米汞柱。生理盐水组有一只山羊需要额外一剂布托啡诺。总体而言，我们的研究结果表明，在给定剂量下，静脉注射利多卡因对接受腹部手术的成年山羊不会产生不良心肺影响。在全身麻醉期间添加利多卡因输注是增强山羊术中镇痛的一种选择。
