Ezell Paula C, Papa Luis, Lawson Gregory W
Division of Laboratory Animal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
J Am Assoc Lab Anim Sci. 2012;51(5):609-15.
Ibuprofen, a nonsteroidal antiinflammatory drug, is a nonselective inhibitor of cyclooxygenases 1 and 2 that commonly is used for its analgesic, antiinflammatory, and antipyretic properties. We compared the palatability and efficacy of medicated water containing ibuprofen from an oral pediatric suspension or liqui-gel capsules in C57BL/6 and genetically engineered mice of C57BL/6 background with ulcerative dermatitis. Mice (n = 14 or 15 per group) with ulcerated skin lesions of similar average size (capsule group, 6.71 mm(2); suspension group, 6.12 mm(2)) received ibuprofen in their drinking water at a concentration of 1 mg/mL. Water and food consumption, locomotor activity, grooming frequency, and reduction in pruritic behavior and lesion size were measured over a 9-d period. Compared with those treated with water containing the suspension, mice that received medicated water containing the liqui-gel formulation drank more (mean, 6.8 compared with 11.7 mL/d), consumed more food (4.02 compared with 2.73 g/d), and showed less pruritic behavior, greater healing (mean, 29.3% compare with 64.8%), and more locomotor activity over a 9-d period.
布洛芬是一种非甾体抗炎药，是环氧化酶1和2的非选择性抑制剂，常用于其止痛、抗炎和解热特性。我们比较了含布洛芬的口服儿科混悬液或液状软胶囊药物水在C57BL/6以及具有溃疡性皮肤炎的C57BL/6背景基因工程小鼠中的适口性和疗效。平均大小相似的皮肤溃疡病变小鼠（每组n = 14或15只）（胶囊组，6.71平方毫米；混悬液组，6.12平方毫米）饮用浓度为1毫克/毫升的含布洛芬饮用水。在9天的时间内测量水和食物消耗量、运动活动、梳理频率以及瘙痒行为和病变大小的减少情况。与饮用含混悬液水的小鼠相比，饮用含液状软胶囊制剂药物水小鼠在9天期间饮水量更多（平均，分别为6.8毫升/天和11.7毫升/天），食物消耗量更多（分别为4.02克/天和2.73克/天），瘙痒行为更少，愈合更好（平均，分别为29.3%和64.8%），运动活动更多。
