• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一名服用卡西酮“浴盐”中毒的年轻男子出现肢体威胁性缺血:病例报告

Limb-Threatening Ischemia in a Young Man with Cathinone "Bath Salt" Intoxication: A Case Report.

作者信息

Saleh Asem, Tittley Jacques, Anand Sonia

机构信息

Department of Vascular Surgery, Hamilton Health Sciences, Hamilton, Ontario, Canada.

Department of Vascular Surgery, Hamilton Health Sciences, Hamilton, Ontario, Canada.

出版信息

Ann Vasc Surg. 2016 Oct;36:294.e1-294.e5. doi: 10.1016/j.avsg.2016.03.025. Epub 2016 Jul 15.

DOI:10.1016/j.avsg.2016.03.025
PMID:27423726
Abstract

"Bath salts" are synthetic designer drugs that have stimulant properties and are a growing medical concern. The chemical compounds in the mixtures have an affinity for receptors in the brain resulting in a stimulant effect similar to that seen with methamphetamines and cocaine. Although illegal in Canada, these drugs are widely available online with over 20 synthetic drugs marketed as "bath salts" and used increasingly among recreational drug users. Much of the medical literature regarding these drugs comes from emergency medicine case reports, which outline the acute, severe medical, and psychiatric effects of "bath salt" toxicity. In this report, we outline severe vascular limb compromise, which occurred in a 24-year-old man who took large doses of bath salts obtained online from China. We detail our experience to re-establish perfusion to the limbs, and the morbidities encountered due to the ischemic insult our patient experienced. The duration and clinical presentation of "bath salt" toxicity are frequently complicated by lack of toxicology screens for the agents on board, and lack of any pharmacokinetic evidence surrounding these synthetic compounds. Although "bath salts" are now illegal in Canada, these drugs are widely available online and have become an increasing public health concern that involves significant morbidity and mortality to users. Creating a base of knowledge and front-line experience are the only current tool in combating the diverse detrimental aftermath of these synthetic agents' abuse.

摘要

“浴盐”是具有兴奋特性的合成设计药物,日益引起医学关注。混合物中的化合物对大脑中的受体具有亲和力,会产生类似于甲基苯丙胺和可卡因的兴奋作用。尽管在加拿大是非法的,但这些药物在网上广泛可得,有20多种合成药物作为“浴盐”销售,越来越多地被娱乐性吸毒者使用。关于这些药物的许多医学文献来自急诊医学病例报告,这些报告概述了“浴盐”中毒的急性、严重医学和精神影响。在本报告中,我们概述了一名24岁男子出现的严重肢体血管损伤情况,该男子服用了从中国网上购得的大量浴盐。我们详细介绍了我们为该患者恢复肢体灌注的经验,以及由于其经历的缺血性损伤而遇到的并发症。“浴盐”中毒的持续时间和临床表现常常因缺乏对体内这些药物的毒理学筛查,以及缺乏围绕这些合成化合物的任何药代动力学证据而变得复杂。尽管“浴盐”目前在加拿大是非法的,但这些药物在网上广泛可得,已成为一个日益严重的公共卫生问题,给使用者带来了重大的发病率和死亡率。积累知识基础和一线经验是目前应对这些合成药物滥用造成的各种有害后果的唯一手段。

相似文献

1
Limb-Threatening Ischemia in a Young Man with Cathinone "Bath Salt" Intoxication: A Case Report.一名服用卡西酮“浴盐”中毒的年轻男子出现肢体威胁性缺血:病例报告
Ann Vasc Surg. 2016 Oct;36:294.e1-294.e5. doi: 10.1016/j.avsg.2016.03.025. Epub 2016 Jul 15.
2
Clinical and pharmacological aspects of bath salt use: a review of the literature and case reports.沐浴盐使用的临床和药理学方面:文献综述和病例报告。
Drug Alcohol Depend. 2013 Sep 1;132(1-2):1-12. doi: 10.1016/j.drugalcdep.2013.06.016. Epub 2013 Aug 1.
3
Psychoactive "bath salts" intoxication with methylenedioxypyrovalerone.精神活性“浴盐”致甲基双氧吡咯戊酮中毒。
Am J Med. 2012 Sep;125(9):854-8. doi: 10.1016/j.amjmed.2012.02.019. Epub 2012 Jun 9.
4
Synthetic cathinones: chemistry, pharmacology and toxicology of a new class of designer drugs of abuse marketed as "bath salts" or "plant food".合成卡西酮:作为“浴盐”或“植物肥料”出售的一类新的设计类滥用药物的化学、药理学和毒理学。
Toxicol Lett. 2012 Jun 1;211(2):144-9. doi: 10.1016/j.toxlet.2012.03.009. Epub 2012 Mar 21.
5
"Bath salts" intoxication: a new recreational drug that presents with a familiar toxidrome.“浴盐”中毒:一种呈现出常见中毒综合征的新型消遣性药物。
CJEM. 2014 Mar;16(2):171-6. doi: 10.2310/8000.2013.131042.
6
Compartment syndrome after "bath salts" use: a case series.“浴盐”使用后的间隔综合征:病例系列。
Ann Emerg Med. 2013 Apr;61(4):480-3. doi: 10.1016/j.annemergmed.2012.11.021. Epub 2013 Jan 12.
7
Crystallographic investigations of select cathinones: emerging illicit street drugs known as `bath salts'.某些卡西酮类物质的晶体学研究:新兴的非法街头毒品“浴盐”。
Acta Crystallogr C Struct Chem. 2015 Jan;71(Pt 1):32-8. doi: 10.1107/S2053229614025637. Epub 2015 Jan 1.
8
Compartment syndrome as a rare complication of iloprost infusion for peripheral vascular disease.
Ann Vasc Surg. 2011 May;25(4):555.e11-2. doi: 10.1016/j.avsg.2010.11.012.
9
The Toxicology Investigators Consortium Case Registry--the 2011 experience.毒理学调查人员联合会病例登记处——2011 年的经验。
J Med Toxicol. 2012 Dec;8(4):360-77. doi: 10.1007/s13181-012-0264-9.
10
Bath salts: an emerging danger.
Del Med J. 2011 Nov;83(11):357-9; quiz 360.

引用本文的文献

1
Cocaine-Induced Four-Extremity Ischemia Caused by a Hypercoagulable State.高凝状态导致的可卡因诱发的四肢缺血
Cureus. 2023 Sep 7;15(9):e44862. doi: 10.7759/cureus.44862. eCollection 2023 Sep.
2
Review article: A comprehensive review of unusual causes of acute limb compartment syndrome.综述文章:急性肢体间隔综合征不常见病因的全面综述。
Emerg Med Australas. 2022 Dec;34(6):871-876. doi: 10.1111/1742-6723.14098. Epub 2022 Oct 3.
3
Human Neuronal Cell Lines as An In Vitro Toxicological Tool for the Evaluation of Novel Psychoactive Substances.
人神经细胞系作为一种新型精神活性物质体外毒理学评价工具。
Int J Mol Sci. 2021 Jun 24;22(13):6785. doi: 10.3390/ijms22136785.
4
Designers Drugs-A New Challenge to Emergency Departments-An Observational Study in Poland.设计药物——急诊科室的新挑战——波兰的一项观察性研究。
Medicina (Kaunas). 2020 Jul 17;56(7):354. doi: 10.3390/medicina56070354.