Saleh Asem, Tittley Jacques, Anand Sonia
Department of Vascular Surgery, Hamilton Health Sciences, Hamilton, Ontario, Canada.
Department of Vascular Surgery, Hamilton Health Sciences, Hamilton, Ontario, Canada.
Ann Vasc Surg. 2016 Oct;36:294.e1-294.e5. doi: 10.1016/j.avsg.2016.03.025. Epub 2016 Jul 15.
"Bath salts" are synthetic designer drugs that have stimulant properties and are a growing medical concern. The chemical compounds in the mixtures have an affinity for receptors in the brain resulting in a stimulant effect similar to that seen with methamphetamines and cocaine. Although illegal in Canada, these drugs are widely available online with over 20 synthetic drugs marketed as "bath salts" and used increasingly among recreational drug users. Much of the medical literature regarding these drugs comes from emergency medicine case reports, which outline the acute, severe medical, and psychiatric effects of "bath salt" toxicity. In this report, we outline severe vascular limb compromise, which occurred in a 24-year-old man who took large doses of bath salts obtained online from China. We detail our experience to re-establish perfusion to the limbs, and the morbidities encountered due to the ischemic insult our patient experienced. The duration and clinical presentation of "bath salt" toxicity are frequently complicated by lack of toxicology screens for the agents on board, and lack of any pharmacokinetic evidence surrounding these synthetic compounds. Although "bath salts" are now illegal in Canada, these drugs are widely available online and have become an increasing public health concern that involves significant morbidity and mortality to users. Creating a base of knowledge and front-line experience are the only current tool in combating the diverse detrimental aftermath of these synthetic agents' abuse.
“浴盐”是具有兴奋特性的合成设计药物,日益引起医学关注。混合物中的化合物对大脑中的受体具有亲和力,会产生类似于甲基苯丙胺和可卡因的兴奋作用。尽管在加拿大是非法的,但这些药物在网上广泛可得,有20多种合成药物作为“浴盐”销售,越来越多地被娱乐性吸毒者使用。关于这些药物的许多医学文献来自急诊医学病例报告,这些报告概述了“浴盐”中毒的急性、严重医学和精神影响。在本报告中,我们概述了一名24岁男子出现的严重肢体血管损伤情况,该男子服用了从中国网上购得的大量浴盐。我们详细介绍了我们为该患者恢复肢体灌注的经验,以及由于其经历的缺血性损伤而遇到的并发症。“浴盐”中毒的持续时间和临床表现常常因缺乏对体内这些药物的毒理学筛查,以及缺乏围绕这些合成化合物的任何药代动力学证据而变得复杂。尽管“浴盐”目前在加拿大是非法的,但这些药物在网上广泛可得,已成为一个日益严重的公共卫生问题,给使用者带来了重大的发病率和死亡率。积累知识基础和一线经验是目前应对这些合成药物滥用造成的各种有害后果的唯一手段。