Zhao Haijing, Zhao Guangyuan, Wang Wenjun
Center for Reproductive Medicine, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, P. R. China.
Center for Reproductive Medicine, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, P. R. China.
Theriogenology. 2016 Oct 15;86(7):1631-6. doi: 10.1016/j.theriogenology.2016.06.004. Epub 2016 Jun 18.
In the modern biological area, the applications of pig as a laboratory model have extensive prospects, such as gene transfer, IVF, SCNT, and xenotransplantation. However, the risk of pathogen transmission by porcine embryos is always a topic to be investigated, especially the viruses related to reproductive failure, for instance, pseudorabies virus, porcine reproductive and respiratory syndrome virus, porcine parvovirus, and porcine circovirus type 2. It should be mentioned that the zona pellucida (ZP) of porcine embryos can be a barrier against the viruses, but certain pathogens may stick to or even pass through the ZP. With intact, free, and damaged ZP, porcine preimplantation embryos are susceptible to these viruses in varying degrees, which may be associated with the virus-specific receptor on embryonic cell membrane. These topics are discussed in the present review.
在现代生物学领域，猪作为实验模型具有广泛的应用前景，如基因转移、体外受精、体细胞核移植和异种移植。然而，猪胚胎传播病原体的风险一直是一个有待研究的课题，尤其是与繁殖失败相关的病毒，例如伪狂犬病病毒、猪繁殖与呼吸综合征病毒、猪细小病毒和猪圆环病毒2型。应该提到的是，猪胚胎的透明带（ZP）可以作为病毒的屏障，但某些病原体可能会粘附甚至穿过透明带。完整、游离和受损的透明带状态下，猪植入前胚胎对这些病毒有不同程度的易感性，这可能与胚胎细胞膜上的病毒特异性受体有关。本综述将讨论这些主题。
