Shahid Saman
Department of Sciences and Humanities, National University of Computer and Emerging Sciences (NUCES)-Foundation for Advancement of Science and Technology (FAST), Lahore, Pakistan.
Crit Rev Oncol Hematol. 2016 Sep;105:145-55. doi: 10.1016/j.critrevonc.2016.06.001. Epub 2016 Jun 29.
We observed the outcomes of chemotherapy with radiotherapy (CR) or radiotherapy (RT) alone for cancer patients of larynx, breast, blood and brain origins through complete blood count (CBC). Following were more depressed in CR patients: mean corpuscular hemoglobin-MCH & lymphocytes-LYM, hematocrit, mean corpuscular hemoglobin concentration-MCHC, hemoglobin-HB and red blood cells-RBC. In RT patients, following were more depressed: LYM, MCH and MCHC. Overall, in all cancer patients, the lymphocytes were depressed 52%. There existed a significant difference between white blood cells and RBC in both CR and RT patients. A significant moderate negative correlation is found in HB with the dose range 30-78 (Gray) given to the CR cancer patients. More number of CBC parameters affected in patients treated with CR and RT; but in less percentage as compared to patients who treated with RT alone. The cancer patients suffered from anemia along with immune modulations from the treatments.
我们通过全血细胞计数（CBC）观察了喉癌、乳腺癌、血癌和脑癌患者接受化疗联合放疗（CR）或单纯放疗（RT）后的结果。CR患者的以下指标降低更为明显：平均红细胞血红蛋白含量（MCH）、淋巴细胞计数（LYM）、血细胞比容、平均红细胞血红蛋白浓度（MCHC）、血红蛋白（HB）和红细胞计数（RBC）。RT患者的以下指标降低更为明显：LYM、MCH和MCHC。总体而言，在所有癌症患者中，淋巴细胞计数降低了52%。CR和RT患者的白细胞和RBC之间存在显著差异。在接受30 - 78（格雷）剂量放疗的CR癌症患者中，HB与剂量范围之间存在显著的中度负相关。接受CR和RT治疗的患者中受影响的CBC参数更多；但与单纯接受RT治疗的患者相比，受影响的百分比更低。癌症患者在接受治疗后出现贫血并伴有免疫调节。
