Long Zhi-Yuan, Wang Ting-Huai
Sheng Li Ke Xue Jin Zhan. 2016 Feb;47(1):21-6.
Ezrin, also known as cytovillin or vilin 2, is one of the members of ERM (Ezrin/Radixin/Moesin) protein family. Ezrin, which is a tyrosine kinase substrate, functions to bridge membrane proteins and the actin cytoskeleton. Recent studies have demonstrated that Ezrin regulates the proliferation, apoptosis, adhesion, invasion, metastasis and angiogenesis of breast cancer cells. These processes are not only associated with changes in expression level and subcellular localization of Ezrin itself, but also influenced by alteration in microenvironment of primary breast cancer cells. The regulation of Ezrin in mammary carcinoma cells involves interactions among signaling pathways mediated by adhesion molecules (CD44, ICAM, E-cadherin) and the tyrosine kinase growth factors, Epidermal Growth Factor (EGF), and Platelet-derived Growth Factor (PDGF) and their receptors. The determination of the functions and mechanism(s) of action of Ezrin in the migration and invasion of breast cancer cells will provide new information on the basic mechanisms of metastasis of breast cancer cells and has the potential to identify a novel drug target for the prevention and treatment of breast cancer. This article addresses the role of Ezrin in the migration and invasion of breast cancer cells.
埃兹蛋白，也被称为细胞绒毛蛋白或绒毛蛋白2，是ERM（埃兹蛋白/根蛋白/膜突蛋白）蛋白家族的成员之一。埃兹蛋白作为一种酪氨酸激酶底物，其作用是连接膜蛋白和肌动蛋白细胞骨架。最近的研究表明，埃兹蛋白调节乳腺癌细胞的增殖、凋亡、黏附、侵袭、转移和血管生成。这些过程不仅与埃兹蛋白自身表达水平和亚细胞定位的变化有关，还受到原发性乳腺癌细胞微环境改变的影响。埃兹蛋白在乳腺癌细胞中的调节涉及由黏附分子（CD44、细胞间黏附分子、E-钙黏蛋白）以及酪氨酸激酶生长因子、表皮生长因子（EGF）和血小板衍生生长因子（PDGF）及其受体介导的信号通路之间的相互作用。确定埃兹蛋白在乳腺癌细胞迁移和侵袭中的功能及作用机制，将为乳腺癌细胞转移的基本机制提供新信息，并有可能确定预防和治疗乳腺癌的新药物靶点。本文探讨了埃兹蛋白在乳腺癌细胞迁移和侵袭中的作用。
