Bathla Nitik, Ahmad Sohaib, Gupta Ravi, Ahmad Shahbaj
Department of Medicine, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Doiwala, Dehradun, India.
Department of Psychiatry and Sleep Clinic, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Doiwala, Dehradun, India.
Saudi J Kidney Dis Transpl. 2016 Jul-Aug;27(4):685-91. doi: 10.4103/1319-2442.185224.
Willis-Ekbom's disease/restless legs syndrome (WED/RLS) has been described in subjects undergoing hemodialysis (HD). Different studies have reported varying prevalence rates and different factors associated with this condition; however, the results are inconsistent. Thus, this study was conducted to assess the prevalence of WED/RLS in patients undergoing HD. Another aim of the study was to identify if any comorbidities or biochemical factors were associated with this condition. A total of 194 adult patients undergoing maintenance HD were included in this study. They were screened for WED/RLS using International RLS Study Group criteria on the face-to-face interview and clinical examination. Most recent laboratory parameters were gathered from the medical records. In addition, seroreactivity to hepatitis B and C was also recorded. The mean age of all the subjects included in the study was 54.4 ± 15 years (range: 18-92 years); 58.2% were males. The mean duration on HD was 36.6 ± 19.3 months. WED/RLS was seen in 5.2% of the study subjects. Subjects with and without WED/RLS were comparable with regard to gender (P = 0.23), adequacy of dialysis (P = 0.82), shift of dialysis (P = 0.93), presence of diabetes mellitus (P = 0.91), hypertension (P = 0.26), smoking (P = 0.22), alcohol use (P = 0.45), and reactivity to hepatitis C (P = 0.19) and hepatitis B (P = 0.80), as well as various hematological and biochemical parameters. The prevalence of WED/RLS of 5% in the HD group was higher than in the general population. However, this study could not find any correlation between RLS and any biochemical parameters or comorbidities. This is an important area to be considered in future and requires more work with larger sample size.
在接受血液透析（HD）的患者中，已发现有不安腿综合征/ Willis-Ekbom病（WED/RLS）。不同研究报告的患病率及与此病症相关的因素各不相同；然而，结果并不一致。因此，开展本研究以评估接受HD治疗的患者中WED/RLS的患病率。该研究的另一目的是确定是否有任何合并症或生化因素与此病症相关。本研究共纳入194例接受维持性HD治疗的成年患者。通过采用国际不安腿综合征研究组的标准，对他们进行面对面访谈和临床检查，以筛查WED/RLS。从病历中收集最近的实验室参数。此外，还记录了乙肝和丙肝的血清反应性。纳入研究的所有受试者的平均年龄为54.4±15岁（范围：18 - 92岁）；男性占58.2%。HD治疗的平均时长为36.6±19.3个月。5.2%的研究对象患有WED/RLS。患有和未患有WED/RLS的受试者在性别（P = 0.23）、透析充分性（P = 0.82）、透析班次（P = 0.93）、是否患有糖尿病（P = 0.91）、高血压（P = 0.26）、吸烟（P = 0.22）、饮酒（P = 0.45）以及丙肝（P = 0.19）和乙肝（P = 0.80）反应性，以及各种血液学和生化参数方面具有可比性。HD组中WED/RLS的患病率为5%，高于一般人群。然而，本研究未发现不安腿综合征与任何生化参数或合并症之间存在关联。这是未来需要考虑的一个重要领域，需要开展更多样本量更大的研究。
