Ali Syed Ahsan, Tariq Muhammad
Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Saudi J Kidney Dis Transpl. 2016 Jul-Aug;27(4):812-5. doi: 10.4103/1319-2442.185270.
Proximal renal tubular acidosis (RTA), also known as Type II RTA, is characterized by a defect in the ability to reabsorb bicarbonate (HCO 3 ) in the proximal tubule. It is usually associated with generalized dysfunction of the proximal tubule as part of Fanconi syndrome. Very few case reports in the literature support Vitamin D deficiency as a cause of proximal RTA. We present a case of a young female who presented with proximal RTA and Fanconi syndrome and excellently responded to Vitamin D replacement. Thus, work-up for the etiology of proximal RTA should include Vitamin D levels since replacement of this vitamin in those who are deficient can lead to cure of such patients.
近端肾小管酸中毒（RTA），也称为II型RTA，其特征是近端小管重吸收碳酸氢盐（HCO₃）的能力存在缺陷。它通常与作为范科尼综合征一部分的近端小管的普遍功能障碍有关。文献中很少有病例报告支持维生素D缺乏是近端RTA的病因。我们报告一例年轻女性病例，该患者表现为近端RTA和范科尼综合征，对维生素D替代治疗反应良好。因此，对近端RTA病因的检查应包括维生素D水平，因为对缺乏这种维生素的患者进行补充可治愈此类患者。
