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Stem Cell Res Ther. 2021 Jul 13;12(1):393. doi: 10.1186/s13287-021-02457-9.
2
Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.遗传性盐丢失性管状病变与免疫缺陷有关，这是由于 IL-17 反应受损所致。
Nat Commun. 2020 Aug 31;11(1):4368. doi: 10.1038/s41467-020-18184-3.
3
Oral Bicarbonate Therapy in Non-Haemodialysis Dependent Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.非血液透析依赖型慢性肾脏病患者的口服碳酸氢盐治疗：随机对照试验的系统评价和荟萃分析
J Clin Med. 2019 Feb 7;8(2):208. doi: 10.3390/jcm8020208.
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Canine mesenchymal stem cells treated with TNF-α and IFN-γ enhance anti-inflammatory effects through the COX-2/PGE pathway.用肿瘤坏死因子-α和干扰素-γ处理的犬间充质干细胞通过环氧化酶-2/前列腺素E途径增强抗炎作用。
Res Vet Sci. 2018 Aug;119:19-26. doi: 10.1016/j.rvsc.2018.05.011. Epub 2018 May 14.
5
Fanconi syndrome in the adulthood. The role of early diagnosis and treatment.成人范科尼综合征。早期诊断与治疗的作用。
J Musculoskelet Neuronal Interact. 2017 Dec 1;17(4):303-306.
6
Regulatory T cells in acute and chronic kidney diseases.调节性 T 细胞在急性和慢性肾脏病中的作用。
Am J Physiol Renal Physiol. 2018 May 1;314(5):F679-F698. doi: 10.1152/ajprenal.00236.2017. Epub 2017 Sep 6.
7
Acquired Fanconi syndrome in two dogs following long-term consumption of pet jerky treats in Japan: case report.日本两只犬长期食用宠物肉干零食后获得性范科尼综合征：病例报告
J Vet Med Sci. 2017 May 3;79(5):818-821. doi: 10.1292/jvms.17-0043. Epub 2017 Apr 1.
8
Successful treatment of proximal renal tubular acidosis and Fanconi syndrome with vitamin D replacement.维生素D替代疗法成功治疗近端肾小管酸中毒和范科尼综合征。
Saudi J Kidney Dis Transpl. 2016 Jul-Aug;27(4):812-5. doi: 10.4103/1319-2442.185270.
9
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In search of mechanisms associated with mesenchymal stem cell-based therapies for acute kidney injury.寻找与基于间充质干细胞的急性肾损伤治疗相关的机制。
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犬脂肪组织来源的间充质干细胞疗法治疗一只患有肾性范科尼综合征的犬

Canine adipose tissue-derived mesenchymal stem cell therapy in a dog with renal Fanconi syndrome.

作者信息

An Ju-Hyun, Kim Kyeong-Bo, Kwon Soon-Chan, Kim Hyeon-Jin, Ryu Min-Ok, Oh Ye-In, Ahn Jin-Ok, Youn Hwa-Young

机构信息

Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.

Ju-Hyun An and Kyeong-Bo Kim contributed equally to this work.

出版信息

Vet Med (Praha). 2022 Feb 1;67(4):206-211. doi: 10.17221/213/2020-VETMED. eCollection 2022 Apr.

DOI:10.17221/213/2020-VETMED
PMID:39170805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11334438/
Abstract

Renal Fanconi syndrome (RFS) affects the proximal tubular resorption in the nephrons. This causes excessive loss of key solutes through the urine. In a canine patient, we successfully managed the renal tubular acidosis and proteinuria caused by RFS via transplantation of canine adipose tissue-derived mesenchymal stem cells (cAT-MSCs). cAT-MSCs were administered ten times at intervals of 2-4 weeks. The post-therapy check-up revealed that the cAT-MSC treatment improved the renal tubular acidosis and proteinuria. Hence, a cAT-MSC transplant may be considered as an adjuvant therapy in veterinary medicine to initiate and maintain relief of RFS-induced acidosis and proteinuria.

摘要

肾性范科尼综合征（RFS）影响肾单位中的近端小管重吸收。这会导致关键溶质通过尿液过度流失。在一只犬类患者中，我们通过移植犬脂肪组织来源的间充质干细胞（cAT-MSCs）成功治疗了由RFS引起的肾小管酸中毒和蛋白尿。cAT-MSCs每隔2-4周给药一次，共给药十次。治疗后的检查显示，cAT-MSC治疗改善了肾小管酸中毒和蛋白尿。因此，cAT-MSC移植可被视为兽医学中的一种辅助疗法，用于启动和维持RFS诱导的酸中毒和蛋白尿的缓解。