Pellegrino M J, Van Fossen D, Gordon C, Ryan J M, Waylonis G W
Department of Physical Medicine, Ohio State University, Columbus.
Arch Phys Med Rehabil. 1989 Jul;70(7):541-3.
Fifty patients with primary fibromyalgia and a negative cardiovascular symptom history underwent echocardiography to determine the prevalence of mitral valve prolapse (MVP). The mean age of the population was 40 +/- 13 years (14 men, 36 women). Mitral valve prolapse was detected in 75%; 33% with myxomatous mitral valve leaflets. The prevalence of MVP in this population is significantly higher (p less than 0.0001) than in the general population. Primary fibromyalgia and MVP may be part of a more generalized connective tissue abnormality characterized by distinct genetically determined variants.
五十名有原发性纤维肌痛且心血管症状史为阴性的患者接受了超声心动图检查，以确定二尖瓣脱垂（MVP）的患病率。该人群的平均年龄为40±13岁（14名男性，36名女性）。75%的患者检测到二尖瓣脱垂；33%的患者二尖瓣叶呈黏液瘤样改变。该人群中MVP的患病率显著高于一般人群（p<0.0001）。原发性纤维肌痛和MVP可能是一种更广泛的结缔组织异常的一部分，其特征为不同的基因决定变体。
