Grigor'ev B A, Kuznetsova Z D
Arkh Patol. 1989;51(4):65-8.
Primary hepatic apudoma associated with serotonin syndrome was recorded in a man of 55 followed up for 6 years. Clinically, there was a progressive enlargement of the liver with varicosis of venae subcutaneae abdominis and venae esophageae. There were also weak signs of carcinoid syndrome. The patient died of acute venous esophageal hemorrhage. The tumor, represented by white dense cystic tissue, was nearly encapsulated and involved almost the whole liver. Histologically, there were monomorphic cells with clear empty or eosinophilic cytoplasm, small central nuclei which developed into solid streaks and alveoli. Glandular formations and pseudorosettes occurred locally. Grimelius staining revealed argyrophil granules in the tumor cells cytoplasm. Metastases of the tumor were found in portal lymph nodes.
一名55岁男性患者被记录患有与血清素综合征相关的原发性肝APUD瘤，随访6年。临床上，肝脏进行性肿大，伴有腹壁皮下静脉和食管静脉曲张。类癌综合征的体征也较轻微。患者死于急性食管静脉出血。肿瘤表现为白色致密囊性组织，几乎被包膜包裹，累及几乎整个肝脏。组织学上，有单形性细胞，胞质清亮、空泡状或嗜酸性，中央小核，形成实性条索和腺泡。局部可见腺管形成和假菊形团。 Grimelius染色显示肿瘤细胞胞质中有嗜银颗粒。在门静脉淋巴结中发现了肿瘤转移。
