Nielsen Joan Bach, Pedersen Ane Matilde, Gribsholt Sigrid Bjerge, Svensson Elisabeth, Richelsen Bjørn
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Surg Obes Relat Dis. 2016 Sep-Oct;12(8):1562-1568. doi: 10.1016/j.soard.2016.04.017. Epub 2016 Apr 20.
Roux-en-Y gastric bypass (RYGB) results in pronounced weight loss in morbidly obese patients but may also cause adverse effects like early dumping and hypoglycemia. Prevalence data on these complications and their potential predictors are sparse.
To assess the prevalence and possible predictors of early dumping and hypoglycemia in a population-based cohort of RYGB patients.
University Hospital, Denmark.
A questionnaire survey was performed in the Central Denmark Region including RYGB-operated patients (years 2006-2011, n = 2238) and a nonoperated comparison cohort (n = 89). The Dumping Rating Scale and the Edinburgh Hypoglycemia Scoring System, together with demographic and clinical characteristics, were used, and possible predictors were examined by logistic regression.
The response rate was 64% (1429/2238). In total, 9.4% (134/1429) and 6.6% (95/1429) experienced moderate or severe symptoms of early dumping and hypoglycemia, respectively, which were significantly higher than in the comparison cohort. Because 3.4% (95% CI: 2.5-4.4) of the RYGB group experienced both early dumping and hypoglycemia, the total prevalence of 1 or both conditions was 12.6 (95% CI 10.9-14.4). Possible predictors for both conditions were body mass index (BMI)<25 kg/m (odds ratio [OR] 1.70 (95% CI: 0.98-2.95) and OR 1.60 (95% CI: .83-3.06), respectively) compared with patients with BMI 25-30 kg/m. Younger age seemed to increase the risk of both conditions (<35 yr: OR 1.75 (95% CI: 1.11-2.75) and OR .59 (95% CI: .93-2.72), respectively) compared with patients>45 years.
Symptoms of early dumping and hypoglycemia were rather common with a prevalence of 1 or both conditions of 12.6% after RYGB. Predictors included younger age and a lower BMI.
Roux-en-Y胃旁路术（RYGB）可使病态肥胖患者显著减重，但也可能导致诸如早期倾倒综合征和低血糖等不良反应。关于这些并发症及其潜在预测因素的患病率数据较少。
评估以人群为基础的RYGB患者队列中早期倾倒综合征和低血糖的患病率及可能的预测因素。
丹麦大学医院。
在丹麦中部地区进行了一项问卷调查，纳入接受RYGB手术的患者（2006 - 2011年，n = 2238）和未接受手术的对照队列（n = 89）。使用倾倒评分量表和爱丁堡低血糖评分系统，以及人口统计学和临床特征，并通过逻辑回归分析可能的预测因素。
应答率为64%（1429/2238）。总体而言，分别有9.4%（134/1429）和6.6%（95/1429）的患者经历了中度或重度早期倾倒综合征和低血糖症状，显著高于对照队列。由于RYGB组中有3.4%（95%CI：2.5 - 4.4）的患者同时经历了早期倾倒综合征和低血糖，因此一种或两种情况的总患病率为12.6%（95%CI 10.9 - 14.4）。与BMI为25 - 30 kg/m²的患者相比，两种情况的可能预测因素均为BMI<25 kg/m²（优势比[OR]分别为1.70（95%CI：0.98 - 2.95）和1.60（95%CI：0.83 - 3.06））。与年龄>45岁的患者相比，年龄较小似乎会增加两种情况的风险（<35岁：OR分别为1.75（95%CI：1.11 - 2.75）和1.59（95%CI：0.93 - 2.72））。
早期倾倒综合征和低血糖症状相当常见，RYGB术后一种或两种情况的患病率为12.6%。预测因素包括年龄较小和BMI较低。
