Lucassen Eliane A, Coomans Claudia P, van Putten Maaike, de Kreij Suzanne R, van Genugten Jasper H L T, Sutorius Robbert P M, de Rooij Karien E, van der Velde Martijn, Verhoeve Sanne L, Smit Jan W A, Löwik Clemens W G M, Smits Hermelijn H, Guigas Bruno, Aartsma-Rus Annemieke M, Meijer Johanna H
Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands.
Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands.
Curr Biol. 2016 Jul 25;26(14):1843-53. doi: 10.1016/j.cub.2016.05.038. Epub 2016 Jul 14.
Circadian rhythms are deeply rooted in the biology of virtually all organisms. The pervasive use of artificial lighting in modern society disrupts circadian rhythms and can be detrimental to our health. To investigate the relationship between disrupting circadian rhythmicity and disease, we exposed mice to continuous light (LL) for 24 weeks and measured several major health parameters. Long-term neuronal recordings revealed that 24 weeks of LL reduced rhythmicity in the central circadian pacemaker of the suprachiasmatic nucleus (SCN) by 70%. Strikingly, LL exposure also reduced skeletal muscle function (forelimb grip strength, wire hanging duration, and grid hanging duration), caused trabecular bone deterioration, and induced a transient pro-inflammatory state. After the mice were returned to a standard light-dark cycle, the SCN neurons rapidly recovered their normal high-amplitude rhythm, and the aforementioned health parameters returned to normal. These findings strongly suggest that a disrupted circadian rhythm reversibly induces detrimental effects on multiple biological processes.
昼夜节律深深植根于几乎所有生物体的生物学特性之中。现代社会中人工照明的广泛使用扰乱了昼夜节律，可能对我们的健康有害。为了研究扰乱昼夜节律与疾病之间的关系，我们将小鼠暴露于持续光照（LL）下24周，并测量了几个主要的健康参数。长期神经元记录显示，24周的LL使视交叉上核（SCN）中央昼夜节律起搏器的节律性降低了70%。令人惊讶的是，暴露于LL还降低了骨骼肌功能（前肢握力、悬线持续时间和网格悬挂持续时间），导致小梁骨退化，并诱导了短暂的促炎状态。在小鼠恢复到标准明暗周期后，SCN神经元迅速恢复其正常的高振幅节律，上述健康参数也恢复正常。这些发现有力地表明，扰乱的昼夜节律会对多个生物过程可逆地诱导有害影响。
