首次从免疫功能低下的儿科患者血液中分离出旺南乔假丝酵母菌。

First isolation of Candida wangnamkhiaoensis from the blood of immunocompromised paediatric patient.

作者信息

Tap Ratna Mohd, Ho Betty Lee Sue, Ramli Nur Yasmin, Suppiah Jeyanthi, Hashim Rohaidah, Sabaratnam Parameswari, Ginsapu Stephanie Jane, Gowbei Annabel, Razak Mohd Fuat Abd, Sipiczki Matthias, Ahmad Norazah

机构信息

Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.

Haematology-Oncology Unit, Paediatric Department, Sarawak General Hospital, Kuching, Sarawak, Malaysia.

出版信息

Mycoses. 2016 Nov;59(11):734-741. doi: 10.1111/myc.12509.

DOI:10.1111/myc.12509

PMID:27427490

Abstract

Candida wangnamkhiaoensis is a species clustered under the Hyphopichia clade has not ever been isolated from any clinical specimens. To the best of our knowledge, this is the first report of C. wangnamkhiaoensis associated with fungaemia in immunocompromised paediatric patient. The isolate was assigned a strain name as UZ1679/14, in which the identification was confirmed by a polymerase chain reaction-sequencing of the internal transcribed spacer (ITS) and large subunit (LSU) regions of the rRNA gene. Antifungal susceptibility pattern showed that the isolate was sensitive to anidulafungin, caspofungin, fluconazole and voriconazole. The patient clinically improved after the antifungal treatment with caspofungin.

摘要

旺南乔念珠菌是一种归类于丝孢酵母属分支下的菌种，从未从任何临床标本中分离出来过。据我们所知，这是首例关于旺南乔念珠菌与免疫功能低下儿科患者真菌血症相关的报告。该分离株被命名为UZ1679/14，通过对rRNA基因的内部转录间隔区（ITS）和大亚基（LSU）区域进行聚合酶链反应测序来确认其鉴定结果。抗真菌药敏试验结果显示，该分离株对阿尼芬净、卡泊芬净、氟康唑和伏立康唑敏感。患者在接受卡泊芬净抗真菌治疗后临床症状有所改善。