Almedawar Mohamad Musbah, Walsh Jason Leo, Isma'eel Hussain A
aVascular Medicine Program, American University of Beirut Medical Centre, Beirut, Lebanon bDivision of Vascular Endothelium and Microcirculation, Department of Medicine III, TU Dresden, Dresden, Germany *Mohamad Musbah Almedawar and Jason Leo Walsh contributed equally to the writing of this article.
Curr Opin Cardiol. 2016 Sep;31(5):545-50. doi: 10.1097/HCO.0000000000000319.
Smoking tobacco using a water pipe is becoming more prevalent globally, particularly amongst younger populations. In addition to its growing popularity, more evidence is emerging regarding associated harm, and several misconceptions exist concerning the likely adverse health effects of waterpipe smoking (WPS). It is timely, therefore, to examine the body of evidence linking WPS to coronary artery disease (CAD). Here, we review the direct evidence linking WPS to CAD and examine additional, indirect evidence of associated harm. We discuss the clinical and public health implications of the current evidence and provide suggestions for further research.
A multicentre case-control study in Lebanon has recently demonstrated an association between WPS and CAD. There are few prior studies making this direct link. However, a large body of evidence has emerged showing close similarities between WPS and cigarette smoking with regard to the toxicity of smoke and acute inflammatory and haemodynamic effects following exposure to it.
There are consistent similarities between WPS and cigarette smoking in regard to association with CAD, the nature of the smoke produced, and the acute haemodynamic effects and inflammatory responses that follow exposure. These findings justify both public health and clinical interventions to reduce WPS. Further studies are warranted to confirm a causal association between WPS and CAD.
使用水烟管吸食烟草在全球范围内正变得越来越普遍,尤其是在年轻人群体中。除了其日益流行外,关于相关危害的证据也越来越多,并且存在一些关于水烟吸食(WPS)可能产生的不良健康影响的误解。因此,及时审视将WPS与冠状动脉疾病(CAD)联系起来的证据体系很有必要。在此,我们回顾将WPS与CAD联系起来的直接证据,并审视相关危害的其他间接证据。我们讨论当前证据对临床和公共卫生的影响,并为进一步研究提供建议。
黎巴嫩的一项多中心病例对照研究最近证明了WPS与CAD之间存在关联。此前很少有研究建立这种直接联系。然而,大量证据表明,在烟雾毒性以及接触烟雾后的急性炎症和血流动力学效应方面,WPS与吸烟有密切相似之处。
在与CAD的关联、所产生烟雾的性质以及接触后急性血流动力学效应和炎症反应方面,WPS与吸烟存在一致的相似之处。这些发现证明了减少WPS的公共卫生和临床干预措施的合理性。有必要进行进一步研究以证实WPS与CAD之间的因果关联。