Panza Gregory A, Taylor Beth A, Thompson Paul D
aDivision of Cardiology, Hartford Hospital, Hartford bDepartment of Kinesiology, University of Connecticut, Storrs, CT, USA.
Curr Opin Cardiol. 2016 Sep;31(5):572-9. doi: 10.1097/HCO.0000000000000317.
This review examined studies published within the last 16 months that investigated the relationship between statins and physical activity.
These recent studies suggest that statins do not adversely affect cardiorespiratory fitness, muscle strength, athletic performance, or physical activity adherence. One recent study comparing patients with statin-associated myalgia and nonstatin-using controls did report that statins are associated with a slowing of time to peak power output, increased abdominal adiposity, and insulin resistance. Statin users also had different muscle gene expression than controls, but conclusions are limited by the design of that study.
Previous reports suggest that statin-associated muscle symptoms such as myalgia, cramps, and weakness occur more frequently in physically active individuals, but the recent studies we reviewed do not provide additional support for this possibility. Well-designed clinical trials are needed to determine whether different statins or statin doses evoke statin-associated muscle symptoms or muscle damage that may reduce cardiorespiratory fitness and adherence to physical activity.
本综述研究了过去16个月内发表的关于他汀类药物与体育活动之间关系的研究。
这些近期研究表明，他汀类药物不会对心肺适能、肌肉力量、运动表现或体育活动依从性产生不利影响。一项近期研究比较了患有他汀类药物相关性肌痛的患者和未使用他汀类药物的对照组，该研究确实报告称，他汀类药物与达到峰值功率输出的时间延长、腹部肥胖增加和胰岛素抵抗有关。他汀类药物使用者的肌肉基因表达也与对照组不同，但该研究的设计限制了结论。
先前的报告表明，他汀类药物相关性肌肉症状，如肌痛、痉挛和无力，在体育活动活跃的个体中更频繁出现，但我们综述的近期研究并未为这种可能性提供更多支持。需要设计良好的临床试验来确定不同的他汀类药物或他汀类药物剂量是否会引发他汀类药物相关性肌肉症状或肌肉损伤，而这可能会降低心肺适能和体育活动依从性。
